Translocation joins c-myc and immunoglobulin γ1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-07

AUTHORS

P. H. Hamlyn, T. H. Rabbitts

ABSTRACT

Recombinant DNA clones have been used to directly demonstrate that the Burkitt lymphoma cell line Raji, t(8;14) (q24;q32), has a rearranged copy of the c-myc gene adjacent to the γ1 constant region gene of the human immunoglobulin heavy-chain locus ; the genes are arranged in the opposite direction for transcription. At least one further 5′ exon has been detected in the normal c-myc gene by analysis of RNA transcripts, and the occurrence of high levels of two c-myc mRNA size classes, both apparently initiating in this exon, is described. More... »

PAGES

135-139

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/304135a0

DOI

http://dx.doi.org/10.1038/304135a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046406871

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6306472


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