Lectin-induced expression of DR antigen on human cultured follicular thyroid cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-07

AUTHORS

R Pujol-Borrell, T Hanafusa, L Chiovato, G F Bottazzo

ABSTRACT

HLA-DR antigens, the human equivalent of mouse I region-associated or Ia products, are polymorphic cell surface sialoglycoproteins involved in initiation of the immune response. Their expression is normally restricted to B lymphocytes, macrophages, dendritic and other antigen-presenting cells and vascular endothelium and possibly some cells of the mucosa lining body cavities. HLA-DR expression can be modified during cell differentiation; B lymphocytes become negative on maturing to plasma cells and human T lymphocytes acquire these antigens when activated in vitro or in vivo. We report here that human thyroid follicular cells which are normally negative for HLA-DR molecules, can be induced to express these antigens when cultured with phytohaemagglutinin (PHA), concanavalin A (Con A) or pokeweed mitogen (PWM). These lectins exert their action directly on the thyroid cells with no concomitant mitogenic effect. More... »

PAGES

71

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/304071a0

DOI

http://dx.doi.org/10.1038/304071a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027273443

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6408485


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