Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-06-01

AUTHORS

Martti Vaara, Timo Vaara

ABSTRACT

A major virulence factor of bacteria that cause generalized infections is their resistance to the lytic action of the complement cascade1, an important defence mechanism of the host. Invasive Gram-negative enteric bacteria, which cause about one-third of all bacteraemic infections2,3, are completely resistant to lysis by complement, even in the presence of hyperim-mune serum4–6. The same bacteria are also resistant to many antibiotics that are effective therapeutic agents against other bacteria, as the outermost surface layer (the outer membrane) of the bacteria functions as a permeability barrier7. Here we show that it is possible to sensitize such bacteria to both complement and antibiotics by using an agent that binds to the outer membrane. This agent is a nontoxic derivative of polymyxin which by itself has no bactericidal action8,9. More... »

PAGES

526-528

References to SciGraph publications

  • 1974-01. Action of polymyxin B on bacterial membranes in ARCHIVES OF MICROBIOLOGY
  • 1976-08. Action of polymyxin B on bacterial membranes in ARCHIVES OF MICROBIOLOGY
  • Journal

    TITLE

    Nature

    ISSUE

    5917

    VOLUME

    303

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/303526a0

    DOI

    http://dx.doi.org/10.1038/303526a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002082480

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6406904


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