Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-06

AUTHORS

Kenneth B. Marcu, Lawrence W. Stanton, Rosemary Watt

ABSTRACT

Comparative nucleotide sequence analysis of a rearranged c-myc gene in a murine plasmacytoma and c-myc cDNA from normal spleen reveals that chromosomal translocation in the plasmacytoma breaks the c-myc gene within the first exon or intron. In the plasmacytoma truncated c-myc RNAs initiate from newly exposed promoter sites. Nevertheless, the myc polypeptide produced in the plasmacytoma is probably the same as that from the intact c-myc gene because the exon lost by breakage and translocation is non-coding. The second and third exons of the mouse c-myc gene are substantially conserved in the v-myc gene of the avian retrovirus, MC29. More... »

PAGES

401

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/303401a0

DOI

http://dx.doi.org/10.1038/303401a0

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6304522


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