A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-06

AUTHORS

Martin C. Raff, Robert H. Miller, Mark Noble

ABSTRACT

We have identified a cell type in 7-day-old rat optic nerve that differentiates into a fibrous astrocyte if cultured in the presence of fetal calf serum and into an oligodendrocyte if cultured in the absence of serum. In certain culture conditions some of these cells acquire a mixed phenotype, displaying properties of both astrocytes and oligodendrocytes. These observations suggest that fibrous astrocytes and oligodendrocytes develop from a common progenitor cell and provide a striking example of developmental plasticity and environmental influence in the differentiation of CNS glial cells. More... »

PAGES

390-396

Journal

TITLE

Nature

ISSUE

5916

VOLUME

303

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/303390a0

    DOI

    http://dx.doi.org/10.1038/303390a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046522629

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6304520


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