Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-03

AUTHORS

Daniel J. Capon, Ellson Y. Chen, Arthur D. Levinson, Peter H. Seeburg, David V. Goeddel

ABSTRACT

DNA sequence analysis of the activated oncogene from the T24 human bladder carcinoma line and two alleles of its normal cellular progenitor (c-Ha-ras-1) indicates that the genes encompass at least four exons, and that only a single point mutation residing within the first exon distinguishes the coding region of both alleles of the normal gene from their activated counterpart. Both versions o f the gene encode a protein which is predicted to differ from the corresponding viral gene product at three amino acid residues, one of which was previously shown to represent the major site of phosphorylation of the viral polypeptide. More... »

PAGES

33-37

References to SciGraph publications

  • 1982-11. Mechanism of activation of a human oncogene in NATURE
  • 1982-07. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes in NATURE
  • 1982-11. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene in NATURE
  • 1981-03. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts in NATURE
  • 1982-06. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene in NATURE
  • 1979-03. Organisation and sequences at the 5′ end of a cloned complete ovalbumin gene in NATURE
  • 1982-06. Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus in NATURE
  • 1981-08. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes in NATURE
  • 1980-04. Transforming activity of DNA of chemically transformed and normal cells in NATURE
  • 1974-11. Sequence at the 3′ end of globin mRNA shows homology with immunoglobulin light chain mRNA in NATURE
  • 1980-10. Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus in NATURE
  • 1982-10. The primary structure and genetic organization of the bovine papillomavirus type 1 genome in NATURE
  • 1982-04. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    5903

    VOLUME

    302

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/302033a0

    DOI

    http://dx.doi.org/10.1038/302033a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031650611

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6298635


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