Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-01

AUTHORS

Diane Pennica, William E. Holmes, William J. Kohr, Richard N. Harkins, Gordon A. Vehar, Carole A. Ward, William F. Bennett, Elizabeth Yelverton, Peter H. Seeburg, Herbert L. Heyneker, David V. Goeddel, Desire Collen

ABSTRACT

Bacterial clones containing human tissue-type plasminogen activator (t-PA) cDNA sequences were identified in a cDNA library prepared using gel-fractionated mRNA from human melanoma cells. A plasmid containing the Escherichia coli trp promoter and the cDNA sequence coding f or the 527-amino acid mature t-PA protein was constructed for expression in E. coli. A polypeptide was produced having the fibrinolytic properties characteristic of authentic human t-PA. More... »

PAGES

214-221

Journal

TITLE

Nature

ISSUE

5897

VOLUME

301

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/301214a0

    DOI

    http://dx.doi.org/10.1038/301214a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007864671

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6337343


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