Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit β-globin gene View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-01

AUTHORS

Berend Wieringa, François Meyer, Jakob Reiser, Charles Weissmann

ABSTRACT

Only one of six point mutations of the sequence around one end of the larger of the introns of the rabbit beta-globin gene seriously affects the normal removal of the intron and splicing of the gene. That mutation converts a GT sequence, invariably found at the 5' end of introns, into an AT, which is no longer recognized as a signal for intron removal. Instead, three normally unused (cryptic) sites are used, leading to aberrant gene transcripts. One of the cryptic sites is an exception to the invariable GT sequence. More... »

PAGES

38

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/301038a0

DOI

http://dx.doi.org/10.1038/301038a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045340357

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6296682


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