Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-12

AUTHORS

Gideon Rechavi, David Givol, Eli Canaani

ABSTRACT

The cellular oncogene c-mos is rearranged in a mouse myeloma and the tumour mRNA contains transcripts hybridizing with a v-mos probe. The rearranged gene (rc-mos) was cloned in λ phage and shown to transform mouse fibroblasts in transfection assays. rc-mos differs from its progenitor, c-mos, only at the 5′ end of the gene, where c-mos sequences have been substituted by a novel cellular DNA fragment. This fragment contains a 159-base pair (bp) insertion sequence (IS)-like element localized immediately 5′ to the junction with c-mos. This is the first demonstration in a non-virally-induced tumour of activation of a cellular oncogene by a mechanism possibly involving DNA transposition. More... »

PAGES

607-611

References to SciGraph publications

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  • 1980-07. The yeast transposon Ty1 generates duplications of target DNA on insertion in NATURE
  • 1979-07. Nucleotide sequences of the attachment sites of bacteriophage Mu DNA in NATURE
  • 1979-11. The transforming gene of Moloney murine sarcoma virus in NATURE
  • 1979-10. A normal cell protein cross-reactive to the major Abelson murine leukaemia virus gene product in NATURE
  • 1981-03. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts in NATURE
  • 1982-01. Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/300607a0

    DOI

    http://dx.doi.org/10.1038/300607a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045054509

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6292737


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