Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-11

AUTHORS

Robert S. Goodenow, Minnie McMillan, Margery Nicolson, Beverly Taylor Sher, Kurt Eakle, Norman Davidson, Leroy Hood

ABSTRACT

DNA-mediated gene transfer was used to identify cloned class I genes from the major histocompatibility complex of the BALB/c mouse. Three genes encoding the transplantation antigens H–2 Kd, Dd and Ld were identified as well as genes encoding the Qa-2,3 and two TL differentiation antigens. As many as 10 putative novel class I genes were detected by the association of their gene products with β2-microglobulin. Alloantiserum prepared to one of the novel antigens was used to demonstrate the expression of the previously undetected antigen on spleen cells of various inbred, congeneic, and recombinant congeneic strains of mice. More... »

PAGES

231-237

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/300231a0

DOI

http://dx.doi.org/10.1038/300231a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007492157

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6815535


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