A molecular map of the immune response region from the major histocompatibility complex of the mouse View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-11

AUTHORS

Michael Steinmetz, Karyl Minard, Suzanna Horvath, Janet McNicholas, Jeffrey Srelinger, Claire Wake, Eric Long, Bernard Mach, Leroy Hood

ABSTRACT

A stretch of 200 kilobases (kb) of DNA from the I region of the mouse major histocompatibility complex has been cloned and characterized. It contains the genes for the biochemically defined class II proteins Eα, Eβ and Aβ. DNA blot analyses suggest that the I region may contain only 6–8 class II genes. Correlation of our molecular map with the genetic map of the I region confines two of the five I subregions, I–J and I–B, to less than 3.4 kb of DNA at the 3′ end of the Eβ gene where a hotspot for recombination has been observed. Indeed, the I–A and I–E subregions may be contiguous. If so, the I–B and I–J subregions are not encoded in the I region between the I–A and I–E subregions. More... »

PAGES

35-42

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/300035a0

DOI

http://dx.doi.org/10.1038/300035a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034833518

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6290895


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