Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-10

AUTHORS

Robert F. Newbold, Robert W. Overell, Jane R. Connell

ABSTRACT

Limited lifespan in normal diploid mammalian cells in culture is well documented1–3 and there is evidence that it is also a property of normal tissues serially transplanted in vivo4,5. In contrast, in favourable growth conditions, cells derived from tumours or premalignant tissue often exhibit unlimited proliferative potential (immortality) both in vitro and in vivo2,4,6–10. Malignant transformation of diploid cells in culture by carcinogens has been clearly demonstrated in several laboratories2,11–13. However, although it has been frequently reported that establishment in culture is one of many alterations in cell behaviour associated with transformation, the induction of immortality and its role in malignancy have not previously been subjected to serious scientific examination. Here, we show that treatment of Syrian hamster cell cultures with carcinogenic chemicals can induce rare immortal variants, the progeny of which then frequently progress to anchorage independence and malignancy after a further period of growth. In addition, by studying the properties of cell lines that are either immortal or anchorage-independent but not both, we have obtained evidence that immortality, although insufficient by itself, may be a prerequisite for malignant transformation. More... »

PAGES

633-635

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/299633a0

DOI

http://dx.doi.org/10.1038/299633a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048731125

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7121596


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