The primary structure and genetic organization of the bovine papillomavirus type 1 genome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1982-10

AUTHORS

Ellson Y. Chen, Peter M. Howley, Arthur D. Levinson, Peter H. Seeburg

ABSTRACT

The complete nucleotide sequence of the doubt-stranded circular DNA of bovine papillomavirus type 1 (BPV-1) was determined. Analysis of this sequence in conjunction with known transcriptional data for the virus provides a basis of determining the organization of the papillomavirus genome. All the major open reading frames are located on the same DNA strand. The region transcribed in BPV-transformed cells contains open frames in all three translational frames whereas the region transcribed in productively infected bovine fibropapillomas is characterized by two large open reading frames partitioned by a single translational stop codon. The localization of sequences diagnostic of promoters and polyadenylation sites suggests that splicing is involved in the biosynthesis of the viral mRNAs. A sequence comparison indicates the genome organization of the bovine papillomavirus and that of the members of the simian virus 40-polyomavirus subgroup to be distinct, suggesting that these two groups of viruses are evolutionarily unrelated. More... »

PAGES

529-534

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

5883

VOLUME

299

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/299529a0

    DOI

    http://dx.doi.org/10.1038/299529a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005941445

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6289124


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