Expression of marine H–2Kb histocompatibility antigen in cells transformed with cloned H–2 genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-08

AUTHORS

A. L. Mellor, L. Golden, E. Weiss, H. Bullman, J. Hurst, E. Simpson, R. F. L. James, A. R. M. Townsend, P. M. Taylor, W. Schmidt, J. Ferluga, L. Leben, M. Santamaria, G. Atfield, H. Festenstein, R. A. Flavell

ABSTRACT

Cosmids containing H–2 histocompatibility antigen genes of the H–2b haplotype have been isolated. One of these genes expresses a 45,000 molecular weight protein, indistinguishable from H–2Kb when introduced into mouse L cells. These H–2Kb transformed L cells can be killed by allospecific anti-H–2Kb cytotoxic T cells. Moreover, when infected with influenza virus, they can be killed by an H–2Kb–restricted, influenza virus–specific cytotoxic T cell line. These results show that expression of the H–2Kb gene product on the L-cell surface is sufficient to make it a target for specific T-cell killing. More... »

PAGES

529-534

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/298529a0

DOI

http://dx.doi.org/10.1038/298529a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026025017

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6285197


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28 schema:description Cosmids containing H–2 histocompatibility antigen genes of the H–2b haplotype have been isolated. One of these genes expresses a 45,000 molecular weight protein, indistinguishable from H–2Kb when introduced into mouse L cells. These H–2Kb transformed L cells can be killed by allospecific anti-H–2Kb cytotoxic T cells. Moreover, when infected with influenza virus, they can be killed by an H–2Kb–restricted, influenza virus–specific cytotoxic T cell line. These results show that expression of the H–2Kb gene product on the L-cell surface is sufficient to make it a target for specific T-cell killing.
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