Modulation of in vitro BFU–E growth by normal Ia-positive T cells is restricted by HLA–DR View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-07

AUTHORS

Beverly Torok-Storb, John A. Hansen

ABSTRACT

The in vitro growth of immature erythroid precursors, assayed as burst forming units (BFU–E), can be enhanced by co-culturing with normal T cells1–3. The growth enhancing effect of normal T cells, however, was shown to be the outcome of at least two functionally distinct subpopulations, one that enhances burst formation and one that limits it3,4. It appears that the T cell population limiting growth enhancement of the erythroid precursors expresses ‘Ia-like’ antigen (Ia+) because treatment of T cells with anti-Ia antibody and complement significantly increased the ability of the remaining T cells to stimulate antologous BFU–E growth3. As BFU–E also seem to express Ia, the inhibiting effect of certain T cells on BFU–E growth may involve the Ia molecule. We show here that the inhibitory effect of Ia+ T cells on BFU–E growth is genetically restricted to cell combinations which are phenotypically identical for at least one HLA–DR (Ia-like) antigen. More... »

PAGES

473-474

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/298473a0

DOI

http://dx.doi.org/10.1038/298473a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050338144

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6211629


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