Germinal centre B cells: antigen specificity and changes in heavy chain class expression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-07

AUTHORS

G. Kraal, I. L. Weissman, E. C. Butcher

ABSTRACT

Germinal centres are histologically defined aggregates of blast cells that occur in B-cell areas of lymphoid tissues after antigenic stimulation. They are believed to be associated with the development of B-cell memory and plasma cell (especially secondary, IgG and IgA) responses1–3. Recent studies of murine lymphoid tissues have defined cell-surface markers that distinguish germinal centre B cells from other mature B cells4–7, permitting their identification and characterization in cell suspensions. Here we have used these markers to define and study germinal centre cells in lymph nodes, and have found that they constitute a unique population of B cells which (1) arises in response to antigenic stimulation, (2) contains nearly all of the demonstrably antigen-specific B cells in the stimulated organ, (3) bears surface IgM after primary stimulation and (4) as a population, demonstrates isotype switching to a predominant surface IgG phenotype after secondary stimulation with specific antigen. These findings demonstrate that germinal centres are a major site of proliferation and differentiation of antigen-specific B cells in vivo, and suggest that the germinal centre microenvironment may have an important role in heavy chain class switching during B-cell responses. More... »

PAGES

377-379

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/298377a0

DOI

http://dx.doi.org/10.1038/298377a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031841826

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6806671


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