T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-07

AUTHORS

Eugenio Santos, Steven R. Tronick, Stuart A. Aaronson, Simonetta Pulciani, Mariano Barbacid

ABSTRACT

A transforming gene isolated from T24 human bladder carcinoma cells is closely related to the BALB murine sarcoma virus (MSV) onc gene (v-bas). This transforming gene is localized to a 4.6 kilobase pair (kbp) region and is expressed as a 1.2-kbp polyadenylated transcript, which contains v-bas related sequences. Moreover, antisera known to detect the immunologically related onc gene products of BALB- and Harvey-MSVs recognized elevated levels of a related protein in T24 cells. The normal human homologue of v-bas was found to be indistinguishable from the T24 oncogene by heteroduplex and restriction enzyme analysis. These results imply that rather subtle genetic alterations have led to the activation of the normal human homologue of v-bas as a human transforming gene. More... »

PAGES

343-347

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/298343a0

DOI

http://dx.doi.org/10.1038/298343a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000056327

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6283384


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