Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-07

AUTHORS

James L. Bittle, Richard A. Houghten, Hannah Alexander, Thomas M. Shinnick, J. Gregor Sutcliffe, Richard A. Lerner, David J. Rowlands, Fred Brown

ABSTRACT

Chemically synthesized peptides corresponding to two different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype-specific virus neutralizing antibody in cattle, guinea pigs and rabbits. A single inoculation of one of these peptides protected guinea pigs against subsequent challenge with the virulent virus.

PAGES

30-33

Journal

TITLE

Nature

ISSUE

5869

VOLUME

298

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/298030a0

    DOI

    http://dx.doi.org/10.1038/298030a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049090502

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7045684


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