Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-06

AUTHORS

Esther H. Chang, Mark E. Furth, Edward M. Scolnick, Douglas R. Lowy

ABSTRACT

A normal human gene homologous to the p21 ras oncogene of Harvey murine sarcoma virus induced oncogenic transformation and high p21 ras levels in murine fibroblasts when this gene was ligated to a control element (the long terminal repeat) from a murine or feline retrovirus. These results indicate that high levels of a gene product encoded by a normal human oncogene can induce tumorigenic transformation. More... »

PAGES

479-483

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/297479a0

DOI

http://dx.doi.org/10.1038/297479a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020097808

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6283358


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