Corticotropin releasing factor produces behavioural activation in rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-05

AUTHORS

Richard E. Sutton, George F. Koob, Michel Le Moal, Jean Rivier, Wylie Vale

ABSTRACT

A 41-residue peptide with high potency and intrinsic activity to stimulate the secretion of corticotropin and β-endorphin by the adenohypophysis has been characterized and synthesized1,2,19. From experience with other hypophysiotropic and brain peptides3–5, and studies suggesting that CRF could act centrally to activate the sympathetic nervous system (M. Brown et al., in preparation), we considered it likely that this corticotropin/β-endorphin releasing factor (CRF) would have direct behavioural actions. We decided to investigate the effects of CRF on a simple measure of activation in the rat, locomotor activity in photocell cages. We report here that centrally injected synthetic CRF produces a dose-dependent locomotor activation in rats. This increase in activity was not produced by peripheral administration of CRF. In an open field test, rats receiving centrally injected CRF exhibited behaviour consistent with an increase in emotionality. These results suggest that CRF may have an activating action in the central nervous system independent of its effects on the anterior pituitary gland. More... »

PAGES

331-333

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/297331a0

DOI

http://dx.doi.org/10.1038/297331a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018926833

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6978997


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