Active chromatin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-05

AUTHORS

Stuart Weisbrod

ABSTRACT

Active genes are packaged into an altered nucleosome structure forming a chromosomal domain defined by increased sensitivity to nucleases. This structure, reflecting a potential for transcription, contains sites hypersensitive to nuclease digestion adjacent to the coding regions and may also be distinguished by specific non-histone proteins, variant or modified histones or modified DNA. Its formation, by unfolding of a tightly packed chromatin fibre by factors which might affect DNA supercoiling, may be the first step in gene activation. More... »

PAGES

289-295

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/297289a0

DOI

http://dx.doi.org/10.1038/297289a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027153090

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6210847


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