1982-04
AUTHORS ABSTRACTAKR mice are viraemic from birth1 and contract leukaemia at high incidence at 6–9 months of age2. They express, in all tissues studied, the ecotropic (mouse infectious) retrovirus AKV1. Rowe3,4 showed, by crossing AKR mice with the low-viraemia, non-leukaemic NIH/Swiss mice, that viraemia and the leukaemic phenotype are linked and carried at two independent loci (Akv-1 and Akv-2). These two loci were shown to represent integrated ecotropic proviruses5,6. As part of a study of the structure of proviruses which arise in the leukaemic thymus of AKR mice, we identified ecotropic-specific hybridization probes from different regions of the AKV genome7. Initial Southern hybridization8 analyses showed that individual leukaemic AKR/Jackson mice, which have been sibling inbred for over 140 generations, had differing numbers of ecotropic proviruses9. We now report analyses showing that AKR/J mice had three common proviruses; however, two additional ecotropic loci were scattered throughout the Jackson Laboratory AKR population. These loci probably arose through reinfection of the germ line and represent a currently occurring amplification of ecotropic proviruses in these inbred mice. More... »
PAGES865-868
http://scigraph.springernature.com/pub.10.1038/296865a0
DOIhttp://dx.doi.org/10.1038/296865a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1050632019
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/7070527
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "AKR murine leukemia virus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromosome Mapping",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Amplification",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genes, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Linkage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred AKR",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Biochemistry and Molecular Biology, Biological Laboratories, Harvard University, 02138, Cambridge, Massachusetts, USA",
"id": "http://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Department of Biochemistry and Molecular Biology, Biological Laboratories, Harvard University, 02138, Cambridge, Massachusetts, USA"
],
"type": "Organization"
},
"familyName": "Herr",
"givenName": "Winship",
"id": "sg:person.01345611254.57",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345611254.57"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biochemistry and Molecular Biology, Biological Laboratories, Harvard University, 02138, Cambridge, Massachusetts, USA",
"id": "http://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Department of Biochemistry and Molecular Biology, Biological Laboratories, Harvard University, 02138, Cambridge, Massachusetts, USA"
],
"type": "Organization"
},
"familyName": "Gilbert",
"givenName": "Walter",
"id": "sg:person.0760144627.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760144627.10"
],
"type": "Person"
}
],
"datePublished": "1982-04",
"datePublishedReg": "1982-04-01",
"description": "AKR mice are viraemic from birth1 and contract leukaemia at high incidence at 6\u20139 months of age2. They express, in all tissues studied, the ecotropic (mouse infectious) retrovirus AKV1. Rowe3,4 showed, by crossing AKR mice with the low-viraemia, non-leukaemic NIH/Swiss mice, that viraemia and the leukaemic phenotype are linked and carried at two independent loci (Akv-1 and Akv-2). These two loci were shown to represent integrated ecotropic proviruses5,6. As part of a study of the structure of proviruses which arise in the leukaemic thymus of AKR mice, we identified ecotropic-specific hybridization probes from different regions of the AKV genome7. Initial Southern hybridization8 analyses showed that individual leukaemic AKR/Jackson mice, which have been sibling inbred for over 140 generations, had differing numbers of ecotropic proviruses9. We now report analyses showing that AKR/J mice had three common proviruses; however, two additional ecotropic loci were scattered throughout the Jackson Laboratory AKR population. These loci probably arose through reinfection of the germ line and represent a currently occurring amplification of ecotropic proviruses in these inbred mice.",
"genre": "article",
"id": "sg:pub.10.1038/296865a0",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "5860",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "296"
}
],
"keywords": [
"AKR/J mice",
"AKR mice",
"NIH/Swiss mice",
"Swiss mice",
"high incidence",
"mice",
"leukaemic phenotype",
"ecotropic provirus",
"provirus",
"viraemia",
"reinfection",
"leukemia",
"incidence",
"thymus",
"months",
"germ line",
"birth1",
"tissue",
"phenotype",
"age2",
"population",
"different regions",
"study",
"loci",
"analysis",
"reintegration",
"amplification",
"hybridization probes",
"lines",
"number",
"independent loci",
"part",
"region",
"probe",
"generation",
"structure"
],
"name": "Germ-line MuLV reintegrations in AKR/J mice",
"pagination": "865-868",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1050632019"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/296865a0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"7070527"
]
}
],
"sameAs": [
"https://doi.org/10.1038/296865a0",
"https://app.dimensions.ai/details/publication/pub.1050632019"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:18",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_179.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/296865a0"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/296865a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/296865a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/296865a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/296865a0'
This table displays all metadata directly associated to this object as RDF triples.
140 TRIPLES
20 PREDICATES
71 URIs
63 LITERALS
16 BLANK NODES