Germ-line MuLV reintegrations in AKR/J mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-04

AUTHORS

Winship Herr, Walter Gilbert

ABSTRACT

AKR mice are viraemic from birth1 and contract leukaemia at high incidence at 6–9 months of age2. They express, in all tissues studied, the ecotropic (mouse infectious) retrovirus AKV1. Rowe3,4 showed, by crossing AKR mice with the low-viraemia, non-leukaemic NIH/Swiss mice, that viraemia and the leukaemic phenotype are linked and carried at two independent loci (Akv-1 and Akv-2). These two loci were shown to represent integrated ecotropic proviruses5,6. As part of a study of the structure of proviruses which arise in the leukaemic thymus of AKR mice, we identified ecotropic-specific hybridization probes from different regions of the AKV genome7. Initial Southern hybridization8 analyses showed that individual leukaemic AKR/Jackson mice, which have been sibling inbred for over 140 generations, had differing numbers of ecotropic proviruses9. We now report analyses showing that AKR/J mice had three common proviruses; however, two additional ecotropic loci were scattered throughout the Jackson Laboratory AKR population. These loci probably arose through reinfection of the germ line and represent a currently occurring amplification of ecotropic proviruses in these inbred mice. More... »

PAGES

865-868

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/296865a0

DOI

http://dx.doi.org/10.1038/296865a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050632019

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7070527


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AKR murine leukemia virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Amplification", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Linkage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred AKR", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Biology, Biological Laboratories, Harvard University, 02138, Cambridge, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Biological Laboratories, Harvard University, 02138, Cambridge, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herr", 
        "givenName": "Winship", 
        "id": "sg:person.01345611254.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345611254.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Biology, Biological Laboratories, Harvard University, 02138, Cambridge, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Biological Laboratories, Harvard University, 02138, Cambridge, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gilbert", 
        "givenName": "Walter", 
        "id": "sg:person.0760144627.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760144627.10"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1982-04", 
    "datePublishedReg": "1982-04-01", 
    "description": "AKR mice are viraemic from birth1 and contract leukaemia at high incidence at 6\u20139 months of age2. They express, in all tissues studied, the ecotropic (mouse infectious) retrovirus AKV1. Rowe3,4 showed, by crossing AKR mice with the low-viraemia, non-leukaemic NIH/Swiss mice, that viraemia and the leukaemic phenotype are linked and carried at two independent loci (Akv-1 and Akv-2). These two loci were shown to represent integrated ecotropic proviruses5,6. As part of a study of the structure of proviruses which arise in the leukaemic thymus of AKR mice, we identified ecotropic-specific hybridization probes from different regions of the AKV genome7. Initial Southern hybridization8 analyses showed that individual leukaemic AKR/Jackson mice, which have been sibling inbred for over 140 generations, had differing numbers of ecotropic proviruses9. We now report analyses showing that AKR/J mice had three common proviruses; however, two additional ecotropic loci were scattered throughout the Jackson Laboratory AKR population. These loci probably arose through reinfection of the germ line and represent a currently occurring amplification of ecotropic proviruses in these inbred mice.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/296865a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5860", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "296"
      }
    ], 
    "keywords": [
      "AKR/J mice", 
      "AKR mice", 
      "NIH/Swiss mice", 
      "Swiss mice", 
      "high incidence", 
      "mice", 
      "leukaemic phenotype", 
      "ecotropic provirus", 
      "provirus", 
      "viraemia", 
      "reinfection", 
      "leukemia", 
      "incidence", 
      "thymus", 
      "months", 
      "germ line", 
      "birth1", 
      "tissue", 
      "phenotype", 
      "age2", 
      "population", 
      "different regions", 
      "study", 
      "loci", 
      "analysis", 
      "reintegration", 
      "amplification", 
      "hybridization probes", 
      "lines", 
      "number", 
      "independent loci", 
      "part", 
      "region", 
      "probe", 
      "generation", 
      "structure"
    ], 
    "name": "Germ-line MuLV reintegrations in AKR/J mice", 
    "pagination": "865-868", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050632019"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/296865a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7070527"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/296865a0", 
      "https://app.dimensions.ai/details/publication/pub.1050632019"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_179.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/296865a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/296865a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/296865a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/296865a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/296865a0'


 

This table displays all metadata directly associated to this object as RDF triples.

140 TRIPLES      20 PREDICATES      71 URIs      63 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/296865a0 schema:about N46c35882742d4bb7a3ad2593a4ce6d76
2 N544951b8fc894c96bc93d014acc8265a
3 N6850208047a548739d9a397bf21b3c9f
4 N732c9c3b86fd477f831e4302b7f8f2b7
5 N7c197185c7714536a380bd899117ca36
6 Naa9e9b5e49fb4b4a83c7bfb1e613c922
7 Nc6b5da661a644d8aae75e95d9938c4f3
8 Nca6749fa1a20424d8847fd14f8e5ed11
9 Ne113dce8cbf244dea7f67d66b9110375
10 anzsrc-for:11
11 anzsrc-for:1112
12 schema:author N5e94c3dfe25a487f9c1418083bfbcbd4
13 schema:datePublished 1982-04
14 schema:datePublishedReg 1982-04-01
15 schema:description AKR mice are viraemic from birth1 and contract leukaemia at high incidence at 6–9 months of age2. They express, in all tissues studied, the ecotropic (mouse infectious) retrovirus AKV1. Rowe3,4 showed, by crossing AKR mice with the low-viraemia, non-leukaemic NIH/Swiss mice, that viraemia and the leukaemic phenotype are linked and carried at two independent loci (Akv-1 and Akv-2). These two loci were shown to represent integrated ecotropic proviruses5,6. As part of a study of the structure of proviruses which arise in the leukaemic thymus of AKR mice, we identified ecotropic-specific hybridization probes from different regions of the AKV genome7. Initial Southern hybridization8 analyses showed that individual leukaemic AKR/Jackson mice, which have been sibling inbred for over 140 generations, had differing numbers of ecotropic proviruses9. We now report analyses showing that AKR/J mice had three common proviruses; however, two additional ecotropic loci were scattered throughout the Jackson Laboratory AKR population. These loci probably arose through reinfection of the germ line and represent a currently occurring amplification of ecotropic proviruses in these inbred mice.
16 schema:genre article
17 schema:isAccessibleForFree false
18 schema:isPartOf Nb2d0af072f3a4b1da3243197f7ff0cd0
19 Nfacd0325bcc34ff28299a9ed11ee6e18
20 sg:journal.1018957
21 schema:keywords AKR mice
22 AKR/J mice
23 NIH/Swiss mice
24 Swiss mice
25 age2
26 amplification
27 analysis
28 birth1
29 different regions
30 ecotropic provirus
31 generation
32 germ line
33 high incidence
34 hybridization probes
35 incidence
36 independent loci
37 leukaemic phenotype
38 leukemia
39 lines
40 loci
41 mice
42 months
43 number
44 part
45 phenotype
46 population
47 probe
48 provirus
49 region
50 reinfection
51 reintegration
52 structure
53 study
54 thymus
55 tissue
56 viraemia
57 schema:name Germ-line MuLV reintegrations in AKR/J mice
58 schema:pagination 865-868
59 schema:productId N44c501fc1a1848a9a960b1e13051cd7b
60 Nb2868d258d594245becfac780213a9a9
61 Nffc44b85175e4033a893074ad5a18c26
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050632019
63 https://doi.org/10.1038/296865a0
64 schema:sdDatePublished 2022-05-20T07:18
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher Naf283b2351024796b8e5e9d5b4664d7a
67 schema:url https://doi.org/10.1038/296865a0
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N1cd8b6a845314b889df05131722e5700 rdf:first sg:person.0760144627.10
72 rdf:rest rdf:nil
73 N44c501fc1a1848a9a960b1e13051cd7b schema:name dimensions_id
74 schema:value pub.1050632019
75 rdf:type schema:PropertyValue
76 N46c35882742d4bb7a3ad2593a4ce6d76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Chromosome Mapping
78 rdf:type schema:DefinedTerm
79 N544951b8fc894c96bc93d014acc8265a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Mice
81 rdf:type schema:DefinedTerm
82 N5e94c3dfe25a487f9c1418083bfbcbd4 rdf:first sg:person.01345611254.57
83 rdf:rest N1cd8b6a845314b889df05131722e5700
84 N6850208047a548739d9a397bf21b3c9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Animals
86 rdf:type schema:DefinedTerm
87 N732c9c3b86fd477f831e4302b7f8f2b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Genetic Linkage
89 rdf:type schema:DefinedTerm
90 N7c197185c7714536a380bd899117ca36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Mice, Inbred AKR
92 rdf:type schema:DefinedTerm
93 Naa9e9b5e49fb4b4a83c7bfb1e613c922 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Genes, Viral
95 rdf:type schema:DefinedTerm
96 Naf283b2351024796b8e5e9d5b4664d7a schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 Nb2868d258d594245becfac780213a9a9 schema:name pubmed_id
99 schema:value 7070527
100 rdf:type schema:PropertyValue
101 Nb2d0af072f3a4b1da3243197f7ff0cd0 schema:volumeNumber 296
102 rdf:type schema:PublicationVolume
103 Nc6b5da661a644d8aae75e95d9938c4f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name AKR murine leukemia virus
105 rdf:type schema:DefinedTerm
106 Nca6749fa1a20424d8847fd14f8e5ed11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name DNA, Viral
108 rdf:type schema:DefinedTerm
109 Ne113dce8cbf244dea7f67d66b9110375 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Gene Amplification
111 rdf:type schema:DefinedTerm
112 Nfacd0325bcc34ff28299a9ed11ee6e18 schema:issueNumber 5860
113 rdf:type schema:PublicationIssue
114 Nffc44b85175e4033a893074ad5a18c26 schema:name doi
115 schema:value 10.1038/296865a0
116 rdf:type schema:PropertyValue
117 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
118 schema:name Medical and Health Sciences
119 rdf:type schema:DefinedTerm
120 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
121 schema:name Oncology and Carcinogenesis
122 rdf:type schema:DefinedTerm
123 sg:journal.1018957 schema:issn 0028-0836
124 1476-4687
125 schema:name Nature
126 schema:publisher Springer Nature
127 rdf:type schema:Periodical
128 sg:person.01345611254.57 schema:affiliation grid-institutes:grid.38142.3c
129 schema:familyName Herr
130 schema:givenName Winship
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345611254.57
132 rdf:type schema:Person
133 sg:person.0760144627.10 schema:affiliation grid-institutes:grid.38142.3c
134 schema:familyName Gilbert
135 schema:givenName Walter
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760144627.10
137 rdf:type schema:Person
138 grid-institutes:grid.38142.3c schema:alternateName Department of Biochemistry and Molecular Biology, Biological Laboratories, Harvard University, 02138, Cambridge, Massachusetts, USA
139 schema:name Department of Biochemistry and Molecular Biology, Biological Laboratories, Harvard University, 02138, Cambridge, Massachusetts, USA
140 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...