Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-04

AUTHORS

Mitchell Goldfarb, Kenji Shimizu, Manuel Perucho, Michael Wigler

ABSTRACT

DNA from T24, a cell line derived from a human bladder carcinoma, can induce the morphological transformation of NIH 3T3 cells. Using techniques of gene rescue to clone the gene responsible for this transformation, we have found that it is human in origin, <5 kilobase pairs in size and is homologous to a 1,100-base polyadenylated RNA species found in T24 and HeLa cells. Blot analysis indicates extensive restriction endonuclease polymorphism near this gene in human DNAs. More... »

PAGES

404-409

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/296404a0

DOI

http://dx.doi.org/10.1038/296404a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034672695

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7063039


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