Further studies on supposed lamarckian inheritance of immunological tolerance View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-01

AUTHORS

L. Brent, P. Chandler, W. Fierz, P. B. Medawar, L. S. Rayfield, E. Simpson

ABSTRACT

We have previously reported1 an unsuccessful attempt to confirm the claim of Gorczynski and Steele2,3 that tolerance to alloantigens, induced by the inoculation of F1 hybrid spleen and bone marrow cells in newborn mice, can be transmitted by males to their offspring. Our study had been designed to reproduce the in vitro data of Gorczynski and Steele and to extend them by the transplantation of F1 hybrid skin allografts. It followed that of Gorczynski and Steele2 very closely but differed from it in two respects: the number of semi-allogeneic lymphoid cells in the inoculum used to establish tolerance in the fathers was 5 × 107 instead of 108 and the ratio of spleen cells to bone marrow cells was 9:1 rather than 1:1. Although we argued1 that it is improbable that these differences of execution could have significantly affected the outcome of the experiments, our departure from the original protocol was nevertheless open to criticism4 and the purpose of the present further study was to repeat the experiments by following Gorczynski and Steele2 in every respect. We also report an attempt to confirm the work of Guttman's group5,6, who claimed that a single CBA male made tolerant to A/J histocompatibility antigens, and mated with normal (CBA × A)F1 females, produced offspring with a higher incidence of hypo- or unresponsiveness to A/J skin or tumour allografts than the offspring derived from normal males. We have again failed to confirm the work of Gorczynski and Steele and, like Steinmuller7, we have been equally unsuccessful in confirming the observations of Guttman et al. More... »

PAGES

242-244

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/295242a0

DOI

http://dx.doi.org/10.1038/295242a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051803121

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7035967


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