Immunohistochemical mapping of vitamin D-dependent calcium-binding protein in brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-12

AUTHORS

Sohan S. Jande, L. Maler, D. Eric M. Lawson

ABSTRACT

The steroid hormone, 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) causes the de novo synthesis of a calcium-binding protein (D-CaBP)1,2. This protein is present in highest concentrations in intestine, kidney and shell gland, across which calcium is transported in relatively large amounts, but it is also found in smaller amounts in several other tissues, including brain3–7. The area of brain with the highest D-CaBP concentration is the cerebellum, where the protein is found only in the Purkinje cells7,8. We have now mapped D-CaBP immuno-histochemically throughout the brain of chicks and rats and present here a list of all positive nuclei. Because certain of these neurones also contain 1,25-(OH)2D3 (ref. 9), we suggest that they are target cells for this hormone, thus broadening the functional significance of vitamin D to include the brain and implicating vitamin D in a more widespread action than simply a role in the calcium translocation mechanism of epithelial cells. More... »

PAGES

765-767

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/294765a0

DOI

http://dx.doi.org/10.1038/294765a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049972342

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7033797


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