Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-12

AUTHORS

Gabriella Galli, Hans Hofstetter, Max L. Birnstiel

ABSTRACT

The split promoter sequences of a tRNALeuCUG gene of Xenopus laevis have been mapped to nucleotides 13-20 and 51-64 of the tRNALeu coding sequences. The sequences closely coincide with two conserved sequence blocks present in all eukaryotic tRNA genes. The two conserved sequence blocks were found to be exchangeable between tRNA genes as chimaeric tRNAMet--tRNALeu genes proved transcriptionally active. Furthermore, two prokaryotic tRNA genes exhibiting strong homologies with the two blocks yielded specific transcripts when tested in an eukaryotic transcriptional system. More... »

PAGES

626-631

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/294626a0

DOI

http://dx.doi.org/10.1038/294626a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040636577

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7312050


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