Clustered arrangement of immunoglobulin λ constant region genes in man View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-12

AUTHORS

Philip A. Hieter, Gregory F. Hollis, Stanley J. Korsmeyer, Thomas A. Waldmann, Philip Leder

ABSTRACT

The immunoglobulin lambda light chain locus of man contains six lambda-like genes arranged tandemly on a 50-kilobase segment of chromosomal DNA. THe sequences of three of these genes correspond to three known non-allelic lambda chain isotypes: Mcg, Ke-Oz- and Ke-Oz+. They surround a highly polymorphic and evidently unstable region that is repeatedly deleted when cloned in Escherichia coli. Three additional, but as yet unlinked, lambda-like sequences have also been cloned, suggesting that the lambda genes form an unexpectedly large family within the human genome. More... »

PAGES

536-540

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/294536a0

DOI

http://dx.doi.org/10.1038/294536a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022601504

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6273747


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