Mouse IgG3 antibodies are highly protective against infection with Streptococcus pneumoniae View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1981-11

AUTHORS

David E. Briles, J. Latham Claflin, Kenneth Schroer, Colynn Forman

ABSTRACT

Carbohydrate and protein antigens have been shown to elicit the bulk of their antibodies in mutually exclusive IgG subclasses in humans, mice, rats and horses1–4. In the mouse, anti-protein antibodies are primarily of the IgG1 subclass, and anti-carbohydrate antibodies are primarily of the IgG3 subclass1,2. We have now demonstrated that mouse IgG3 antibodies to the phosphocholine (PC) determinant of pneumococcal C-carbohydrate5,6 and to type 3 pneumococcal polysaccharide are highly protective against experimental type 3 pneumococcal infection. This is the first demonstration that antibodies of the IgG3 subclass can protect against bacterial infection. More... »

PAGES

88-90

Journal

TITLE

Nature

ISSUE

5836

VOLUME

294

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/294088a0

DOI

http://dx.doi.org/10.1038/294088a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053732569

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6170000


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