Calcium-binding protein parvalbumin as a neuronal marker View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-09

AUTHORS

M R Celio, C W Heizmann

ABSTRACT

Ca2+ ions, involved in the control of many important physiological functions, require the presence of specific intracellular Ca2+-binding proteins to exert their regulatory roles. Many of the latter have been extracted and purified. Thus, troponin-C regulates muscle contraction1 and calmodulin is involved in a variety of fundamental cellular activities2,3. Parvalbumin seems to be restricted to muscle and brain4–6 but its physiological role is not yet clear. In muscle it probably participates in a regulatory system operating mainly in fast contracting muscles7,8, but in brain, even its anatomical distribution is unknown. We now describe the localization by immunohistological means of parvalbumin in neurones scattered throughout the central nervous system of the rat. Although the distributions of parvalbumin- and GABAergic neurones are similar, the physiological function of parvalbumin-immunoreactive neurones is not yet recognizable. More... »

PAGES

300-302

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/293300a0

DOI

http://dx.doi.org/10.1038/293300a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028031694

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7278987


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebellum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parvalbumins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "gamma-Aminobutyric Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Celio", 
        "givenName": "M R", 
        "id": "sg:person.0642245466.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642245466.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Heizmann", 
        "givenName": "C W", 
        "id": "sg:person.01257747106.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257747106.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1113/jphysiol.1980.sp013358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002221183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.49.070180.002421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017331883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ne.02.030179.002051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018110912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.84.1.66", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023779406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1973.tb04236.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024117185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(77)80064-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025894188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/285073a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030530148", 
          "https://doi.org/10.1038/285073a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(76)80017-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031360685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.45.070176.002235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031509825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.85.2.473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031894855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(77)80289-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039662231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2795(78)90584-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043729726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074645227", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082862458", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1981-09", 
    "datePublishedReg": "1981-09-01", 
    "description": "Ca2+ ions, involved in the control of many important physiological functions, require the presence of specific intracellular Ca2+-binding proteins to exert their regulatory roles. Many of the latter have been extracted and purified. Thus, troponin-C regulates muscle contraction1 and calmodulin is involved in a variety of fundamental cellular activities2,3. Parvalbumin seems to be restricted to muscle and brain4\u20136 but its physiological role is not yet clear. In muscle it probably participates in a regulatory system operating mainly in fast contracting muscles7,8, but in brain, even its anatomical distribution is unknown. We now describe the localization by immunohistological means of parvalbumin in neurones scattered throughout the central nervous system of the rat. Although the distributions of parvalbumin- and GABAergic neurones are similar, the physiological function of parvalbumin-immunoreactive neurones is not yet recognizable.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/293300a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5830", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "293"
      }
    ], 
    "name": "Calcium-binding protein parvalbumin as a neuronal marker", 
    "pagination": "300-302", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "858996a7cd563241b17653c462de69573fc704d60e2b9669e41935708527b274"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7278987"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/293300a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028031694"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/293300a0", 
      "https://app.dimensions.ai/details/publication/pub.1028031694"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/293300a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/293300a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/293300a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/293300a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/293300a0'


 

This table displays all metadata directly associated to this object as RDF triples.

152 TRIPLES      21 PREDICATES      53 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/293300a0 schema:about N07f714410cc3413dad43962815f31bdf
2 N1b40f909256946289432e390a290e7ed
3 N3fa6edfe271e4ea3a52bc540cc5ca967
4 N50000bbbc0c04427b9fbcefde4e017e2
5 N926c11d094634734ab3c073d8242909d
6 N9610161ae967463f9317157e6a9c5ff2
7 Na0f2950bb38e45f98ef072cba6019ab5
8 Nbc763f153b1349d682a89284aa30e3f3
9 Nbfa0edb7b9104686b11de484508eddff
10 Nd6a8a59cb466449fb67bd5cd50d85acb
11 anzsrc-for:11
12 anzsrc-for:1109
13 schema:author Nefa6ef4914f34e5292e6a22ce3b4132a
14 schema:citation sg:pub.10.1038/285073a0
15 https://app.dimensions.ai/details/publication/pub.1074645227
16 https://app.dimensions.ai/details/publication/pub.1082862458
17 https://doi.org/10.1016/0005-2795(78)90584-6
18 https://doi.org/10.1016/0014-5793(77)80064-1
19 https://doi.org/10.1016/0014-5793(77)80289-5
20 https://doi.org/10.1016/s0022-2836(76)80017-4
21 https://doi.org/10.1083/jcb.84.1.66
22 https://doi.org/10.1083/jcb.85.2.473
23 https://doi.org/10.1111/j.1471-4159.1973.tb04236.x
24 https://doi.org/10.1113/jphysiol.1980.sp013358
25 https://doi.org/10.1146/annurev.bi.45.070176.002235
26 https://doi.org/10.1146/annurev.bi.49.070180.002421
27 https://doi.org/10.1146/annurev.ne.02.030179.002051
28 schema:datePublished 1981-09
29 schema:datePublishedReg 1981-09-01
30 schema:description Ca2+ ions, involved in the control of many important physiological functions, require the presence of specific intracellular Ca2+-binding proteins to exert their regulatory roles. Many of the latter have been extracted and purified. Thus, troponin-C regulates muscle contraction1 and calmodulin is involved in a variety of fundamental cellular activities2,3. Parvalbumin seems to be restricted to muscle and brain4–6 but its physiological role is not yet clear. In muscle it probably participates in a regulatory system operating mainly in fast contracting muscles7,8, but in brain, even its anatomical distribution is unknown. We now describe the localization by immunohistological means of parvalbumin in neurones scattered throughout the central nervous system of the rat. Although the distributions of parvalbumin- and GABAergic neurones are similar, the physiological function of parvalbumin-immunoreactive neurones is not yet recognizable.
31 schema:genre research_article
32 schema:inLanguage en
33 schema:isAccessibleForFree false
34 schema:isPartOf N35490d606e194382aa9e5d4f25737f36
35 N8a6f94d82723405ea800129460c9e96c
36 sg:journal.1018957
37 schema:name Calcium-binding protein parvalbumin as a neuronal marker
38 schema:pagination 300-302
39 schema:productId N16bf232cb9674633ad15ba82a39ffac8
40 N2a4b087462e34a24af599128cc2d7c47
41 N53c8414209ea42049eaa82c4ea1de5ae
42 N5c25d55605a44a8cbc8b4708dc3c58aa
43 N845dcbed0b3f4d60b9e2b961f4482f86
44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028031694
45 https://doi.org/10.1038/293300a0
46 schema:sdDatePublished 2019-04-10T13:55
47 schema:sdLicense https://scigraph.springernature.com/explorer/license/
48 schema:sdPublisher N808783a58d844d9b83c5f1718844d17e
49 schema:url http://www.nature.com/articles/293300a0
50 sgo:license sg:explorer/license/
51 sgo:sdDataset articles
52 rdf:type schema:ScholarlyArticle
53 N07f714410cc3413dad43962815f31bdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
54 schema:name Rats
55 rdf:type schema:DefinedTerm
56 N16bf232cb9674633ad15ba82a39ffac8 schema:name dimensions_id
57 schema:value pub.1028031694
58 rdf:type schema:PropertyValue
59 N1b40f909256946289432e390a290e7ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Brain
61 rdf:type schema:DefinedTerm
62 N2a4b087462e34a24af599128cc2d7c47 schema:name readcube_id
63 schema:value 858996a7cd563241b17653c462de69573fc704d60e2b9669e41935708527b274
64 rdf:type schema:PropertyValue
65 N35490d606e194382aa9e5d4f25737f36 schema:volumeNumber 293
66 rdf:type schema:PublicationVolume
67 N3fa6edfe271e4ea3a52bc540cc5ca967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Cerebellum
69 rdf:type schema:DefinedTerm
70 N50000bbbc0c04427b9fbcefde4e017e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Parvalbumins
72 rdf:type schema:DefinedTerm
73 N53c8414209ea42049eaa82c4ea1de5ae schema:name doi
74 schema:value 10.1038/293300a0
75 rdf:type schema:PropertyValue
76 N5c25d55605a44a8cbc8b4708dc3c58aa schema:name nlm_unique_id
77 schema:value 0410462
78 rdf:type schema:PropertyValue
79 N808783a58d844d9b83c5f1718844d17e schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N845dcbed0b3f4d60b9e2b961f4482f86 schema:name pubmed_id
82 schema:value 7278987
83 rdf:type schema:PropertyValue
84 N8a6f94d82723405ea800129460c9e96c schema:issueNumber 5830
85 rdf:type schema:PublicationIssue
86 N926c11d094634734ab3c073d8242909d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Muscle Proteins
88 rdf:type schema:DefinedTerm
89 N9610161ae967463f9317157e6a9c5ff2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Neurons
91 rdf:type schema:DefinedTerm
92 Na0f2950bb38e45f98ef072cba6019ab5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name gamma-Aminobutyric Acid
94 rdf:type schema:DefinedTerm
95 Nbc763f153b1349d682a89284aa30e3f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Cerebral Cortex
97 rdf:type schema:DefinedTerm
98 Nbfa0edb7b9104686b11de484508eddff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Animals
100 rdf:type schema:DefinedTerm
101 Nd6a8a59cb466449fb67bd5cd50d85acb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Calcium-Binding Proteins
103 rdf:type schema:DefinedTerm
104 Ne86d4e83b5a04f06a5b35d180c615521 rdf:first sg:person.01257747106.47
105 rdf:rest rdf:nil
106 Nefa6ef4914f34e5292e6a22ce3b4132a rdf:first sg:person.0642245466.26
107 rdf:rest Ne86d4e83b5a04f06a5b35d180c615521
108 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
109 schema:name Medical and Health Sciences
110 rdf:type schema:DefinedTerm
111 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
112 schema:name Neurosciences
113 rdf:type schema:DefinedTerm
114 sg:journal.1018957 schema:issn 0090-0028
115 1476-4687
116 schema:name Nature
117 rdf:type schema:Periodical
118 sg:person.01257747106.47 schema:familyName Heizmann
119 schema:givenName C W
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257747106.47
121 rdf:type schema:Person
122 sg:person.0642245466.26 schema:familyName Celio
123 schema:givenName M R
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642245466.26
125 rdf:type schema:Person
126 sg:pub.10.1038/285073a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030530148
127 https://doi.org/10.1038/285073a0
128 rdf:type schema:CreativeWork
129 https://app.dimensions.ai/details/publication/pub.1074645227 schema:CreativeWork
130 https://app.dimensions.ai/details/publication/pub.1082862458 schema:CreativeWork
131 https://doi.org/10.1016/0005-2795(78)90584-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043729726
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1016/0014-5793(77)80064-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025894188
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1016/0014-5793(77)80289-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039662231
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1016/s0022-2836(76)80017-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031360685
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1083/jcb.84.1.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023779406
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1083/jcb.85.2.473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031894855
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1111/j.1471-4159.1973.tb04236.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024117185
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1113/jphysiol.1980.sp013358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002221183
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1146/annurev.bi.45.070176.002235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031509825
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1146/annurev.bi.49.070180.002421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017331883
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1146/annurev.ne.02.030179.002051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018110912
152 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...