The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-08

AUTHORS

Ronald W. Ellis, Deborah DeFeo, Thomas Y. Shih, Matthew A. Gonda, Howard A. Young, Nobuo Tsuchida, Douglas R. Lowy, Edward M. Scolnick

ABSTRACT

The Harvey and Kirsten strains of murine sarcoma virus encode enzymatically and serologically related p21 src proteins which are required for virally mediated cellular transformation. The genes in each virus encoding p21 show such extensive divergence from each other that cloned probes from these genes detect distinct sets of cellular genes in the DNA from several vertebrate species. These data suggest that cellular p21 sarc genes constitute a divergent family of vertebrate genes that can regulate the growth of cells. More... »

PAGES

506-511

Journal

TITLE

Nature

ISSUE

5823

VOLUME

292

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/292506a0

DOI

http://dx.doi.org/10.1038/292506a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018622270

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6265801


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