Efficient replication between non-hydrogen-bonded nucleoside shape analogs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-11

AUTHORS

Juan C. Morales, Eric T. Kool

ABSTRACT

DNA polymerase enzymes make an error only once per 10(4)-10(5) initial nucleotide insertions during DNA replication. Most currently held models of this high fidelity cite the hydrogen bonds between complementary pyrimidines and purines as a critical controlling factor. Testing this has been difficult, however, since standard molecular strategies for blocking or removing polar hydrogen-bonding groups cause changes to size and shape as well as hydrogen bonding ability. One answer to this problem is the use of nonpolar molecules that mimic the shape of natural DNA bases. Here we show that a non-hydrogen-bonding shape mimic for adenine is replicated efficiently and selectively against a nonpolar shape mimic for thymine. The results establish that hydrogen bonds in a base pair are not absolutely required for efficient nucleotide insertion. This adds support to the idea that shape complementarity may play as important a role in replication as base-base hydrogen bonds. More... »

PAGES

nsb1198_950

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/2925

DOI

http://dx.doi.org/10.1038/2925

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032653737

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9808038


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