Immunological enhancement of tumour allografts following treatment of mice with TNP-conjugated alloantigen and anti-TNP antibody View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-07

AUTHORS

I. V. Hutchinson, L. Brent

ABSTRACT

Immunological enhancement—the prolonged survival of tumour or organ allografts brought about by passive immunization of the host with alloantibody directed against the graft's antigens—has not yet been applied successfully to clinical organ transplantation. There are many reasons for this, among them the difficulty of preparing the required battery of alloantisera and the danger of causing hyperacute rejection of kidney allografts. We show here that it should be possible to circumvent both these problems by using a xenogeneic antibody directed against a well defined hapten rather than against histocompatibility antigens. More... »

PAGES

353-355

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/292353a0

DOI

http://dx.doi.org/10.1038/292353a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029895560

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7254335


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