The expression-linked copy of surface antigen gene in Trypanosoma is probably the one transcribed View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-07

AUTHORS

E. Pays, M. Lheureux, M. Steinert

ABSTRACT

The antigenic specificity of the living trypanosome seems to be determined by the protein component of a unique glycoprotein species covering the whole surface of the parasite. During chronic infection, a single clone of trypanosomes may successively express a large repertoire of different variable antigen types (VATs). There are probably as many genes as variant-specific antigens (VSAs) (see refs 1–3 for reviews). The expression of the genes coding for the synthesis of these antigens is linked to genomic rearrangements involving duplication of the coding sequence and transposition of the additional copy4–6. The regulation of the expression of the VSA genes is operated at the transcriptional level7–10. It can thus be supposed that their transcription depends on the presence of the additional, transposed copy. We report here that this additional copy is in a chromatin configuration highly sensitive to pancreatic deoxyribonuclease, suggesting that it is the transcribed one. More... »

PAGES

265-267

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/292265a0

DOI

http://dx.doi.org/10.1038/292265a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051365234

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7254319


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxyribonucleases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trypanosoma brucei brucei", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "D\u00e9partement de Biologie Mol\u00e9culaire, Universit\u00e9 libre de Bruxelles, 67, rue des Chevaux, 1640, Rhode St Gen\u00e8se, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "D\u00e9partement de Biologie Mol\u00e9culaire, Universit\u00e9 libre de Bruxelles, 67, rue des Chevaux, 1640, Rhode St Gen\u00e8se, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pays", 
        "givenName": "E.", 
        "id": "sg:person.0632561176.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632561176.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9partement de Biologie Mol\u00e9culaire, Universit\u00e9 libre de Bruxelles, 67, rue des Chevaux, 1640, Rhode St Gen\u00e8se, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "D\u00e9partement de Biologie Mol\u00e9culaire, Universit\u00e9 libre de Bruxelles, 67, rue des Chevaux, 1640, Rhode St Gen\u00e8se, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lheureux", 
        "givenName": "M.", 
        "id": "sg:person.01174472237.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174472237.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9partement de Biologie Mol\u00e9culaire, Universit\u00e9 libre de Bruxelles, 67, rue des Chevaux, 1640, Rhode St Gen\u00e8se, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "D\u00e9partement de Biologie Mol\u00e9culaire, Universit\u00e9 libre de Bruxelles, 67, rue des Chevaux, 1640, Rhode St Gen\u00e8se, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steinert", 
        "givenName": "M.", 
        "id": "sg:person.0723207553.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723207553.85"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/273613a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026570145", 
          "https://doi.org/10.1038/273613a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/284078a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004894984", 
          "https://doi.org/10.1038/284078a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1981-07", 
    "datePublishedReg": "1981-07-01", 
    "description": "The antigenic specificity of the living trypanosome seems to be determined by the protein component of a unique glycoprotein species covering the whole surface of the parasite. During chronic infection, a single clone of trypanosomes may successively express a large repertoire of different variable antigen types (VATs). There are probably as many genes as variant-specific antigens (VSAs) (see refs 1\u20133 for reviews). The expression of the genes coding for the synthesis of these antigens is linked to genomic rearrangements involving duplication of the coding sequence and transposition of the additional copy4\u20136. The regulation of the expression of the VSA genes is operated at the transcriptional level7\u201310. It can thus be supposed that their transcription depends on the presence of the additional, transposed copy. We report here that this additional copy is in a chromatin configuration highly sensitive to pancreatic deoxyribonuclease, suggesting that it is the transcribed one.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/292265a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5820", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "292"
      }
    ], 
    "keywords": [
      "expression-linked copy", 
      "variant-specific antigens", 
      "chromatin configuration", 
      "genomic rearrangements", 
      "surface antigen gene", 
      "protein components", 
      "VSA genes", 
      "glycoprotein species", 
      "additional copies", 
      "large repertoire", 
      "genes", 
      "different variable antigen types", 
      "single clone", 
      "variable antigen types", 
      "antigen gene", 
      "pancreatic deoxyribonuclease", 
      "trypanosomes", 
      "copies", 
      "expression", 
      "transcription", 
      "duplication", 
      "clones", 
      "species", 
      "Trypanosoma", 
      "regulation", 
      "parasites", 
      "sequence", 
      "deoxyribonuclease", 
      "antigenic specificity", 
      "rearrangement", 
      "repertoire", 
      "specificity", 
      "transposition", 
      "chronic infection", 
      "antigen types", 
      "antigen", 
      "synthesis", 
      "presence", 
      "components", 
      "infection", 
      "types", 
      "one", 
      "surface", 
      "whole surface", 
      "configuration", 
      "unique glycoprotein species", 
      "additional copy4", 
      "copy4", 
      "transcriptional level7", 
      "level7", 
      "transcribed one"
    ], 
    "name": "The expression-linked copy of surface antigen gene in Trypanosoma is probably the one transcribed", 
    "pagination": "265-267", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051365234"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/292265a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7254319"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/292265a0", 
      "https://app.dimensions.ai/details/publication/pub.1051365234"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_160.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/292265a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/292265a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/292265a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/292265a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/292265a0'


 

This table displays all metadata directly associated to this object as RDF triples.

171 TRIPLES      22 PREDICATES      89 URIs      79 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/292265a0 schema:about N12ff89e64131473e9a6a8415a2d4d3de
2 N139540424055476b8ced560391fb0c3f
3 N192e6382ca7c4ed1a6cc2731154b4c29
4 N29c4ae44db8b4d468cb6da64536ca2a8
5 N97220d73d6904590b14c4f73c25e7ec2
6 Nb86ed34a2cd944618fba37b225b66869
7 Nbc7be2be871d4640a7920948714b699b
8 Ndee1bfdac4454511ab4729fad0a8711a
9 Neef6107689484dac9a586b3e44729750
10 anzsrc-for:06
11 anzsrc-for:0604
12 schema:author Ndcaeb34e65d84a69b4c423996e19cc55
13 schema:citation sg:pub.10.1038/273613a0
14 sg:pub.10.1038/284078a0
15 schema:datePublished 1981-07
16 schema:datePublishedReg 1981-07-01
17 schema:description The antigenic specificity of the living trypanosome seems to be determined by the protein component of a unique glycoprotein species covering the whole surface of the parasite. During chronic infection, a single clone of trypanosomes may successively express a large repertoire of different variable antigen types (VATs). There are probably as many genes as variant-specific antigens (VSAs) (see refs 1–3 for reviews). The expression of the genes coding for the synthesis of these antigens is linked to genomic rearrangements involving duplication of the coding sequence and transposition of the additional copy4–6. The regulation of the expression of the VSA genes is operated at the transcriptional level7–10. It can thus be supposed that their transcription depends on the presence of the additional, transposed copy. We report here that this additional copy is in a chromatin configuration highly sensitive to pancreatic deoxyribonuclease, suggesting that it is the transcribed one.
18 schema:genre article
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N809710f5ecea41b2a7e9549360067d60
22 Nbd34fe572c0a4272b2d010f4fa6e7da3
23 sg:journal.1018957
24 schema:keywords Trypanosoma
25 VSA genes
26 additional copies
27 additional copy4
28 antigen
29 antigen gene
30 antigen types
31 antigenic specificity
32 chromatin configuration
33 chronic infection
34 clones
35 components
36 configuration
37 copies
38 copy4
39 deoxyribonuclease
40 different variable antigen types
41 duplication
42 expression
43 expression-linked copy
44 genes
45 genomic rearrangements
46 glycoprotein species
47 infection
48 large repertoire
49 level7
50 one
51 pancreatic deoxyribonuclease
52 parasites
53 presence
54 protein components
55 rearrangement
56 regulation
57 repertoire
58 sequence
59 single clone
60 species
61 specificity
62 surface
63 surface antigen gene
64 synthesis
65 transcribed one
66 transcription
67 transcriptional level7
68 transposition
69 trypanosomes
70 types
71 unique glycoprotein species
72 variable antigen types
73 variant-specific antigens
74 whole surface
75 schema:name The expression-linked copy of surface antigen gene in Trypanosoma is probably the one transcribed
76 schema:pagination 265-267
77 schema:productId N2605771d0f944e738447f32c6ecbcc81
78 N9db34ba2a73442ed8272c9fc8d765135
79 Nfcb737ea93224d10b3f54a7b21c2e2b1
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051365234
81 https://doi.org/10.1038/292265a0
82 schema:sdDatePublished 2021-12-01T19:04
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nd35fbcf99c114b74ac5011cf90e095ea
85 schema:url https://doi.org/10.1038/292265a0
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N03f3307fd82945339adb10eb613135b1 rdf:first sg:person.0723207553.85
90 rdf:rest rdf:nil
91 N12ff89e64131473e9a6a8415a2d4d3de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Antigens, Surface
93 rdf:type schema:DefinedTerm
94 N139540424055476b8ced560391fb0c3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Gene Expression Regulation
96 rdf:type schema:DefinedTerm
97 N192e6382ca7c4ed1a6cc2731154b4c29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Animals
99 rdf:type schema:DefinedTerm
100 N2605771d0f944e738447f32c6ecbcc81 schema:name doi
101 schema:value 10.1038/292265a0
102 rdf:type schema:PropertyValue
103 N29c4ae44db8b4d468cb6da64536ca2a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Chromatin
105 rdf:type schema:DefinedTerm
106 N809710f5ecea41b2a7e9549360067d60 schema:issueNumber 5820
107 rdf:type schema:PublicationIssue
108 N97220d73d6904590b14c4f73c25e7ec2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Genes
110 rdf:type schema:DefinedTerm
111 N9db34ba2a73442ed8272c9fc8d765135 schema:name dimensions_id
112 schema:value pub.1051365234
113 rdf:type schema:PropertyValue
114 Nb86ed34a2cd944618fba37b225b66869 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Kinetics
116 rdf:type schema:DefinedTerm
117 Nbc7be2be871d4640a7920948714b699b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Transcription, Genetic
119 rdf:type schema:DefinedTerm
120 Nbd34fe572c0a4272b2d010f4fa6e7da3 schema:volumeNumber 292
121 rdf:type schema:PublicationVolume
122 Nd1ab244a2e8941ecb3a78ff63d5a677d rdf:first sg:person.01174472237.11
123 rdf:rest N03f3307fd82945339adb10eb613135b1
124 Nd35fbcf99c114b74ac5011cf90e095ea schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 Ndcaeb34e65d84a69b4c423996e19cc55 rdf:first sg:person.0632561176.75
127 rdf:rest Nd1ab244a2e8941ecb3a78ff63d5a677d
128 Ndee1bfdac4454511ab4729fad0a8711a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Deoxyribonucleases
130 rdf:type schema:DefinedTerm
131 Neef6107689484dac9a586b3e44729750 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Trypanosoma brucei brucei
133 rdf:type schema:DefinedTerm
134 Nfcb737ea93224d10b3f54a7b21c2e2b1 schema:name pubmed_id
135 schema:value 7254319
136 rdf:type schema:PropertyValue
137 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
138 schema:name Biological Sciences
139 rdf:type schema:DefinedTerm
140 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
141 schema:name Genetics
142 rdf:type schema:DefinedTerm
143 sg:journal.1018957 schema:issn 0028-0836
144 1476-4687
145 schema:name Nature
146 schema:publisher Springer Nature
147 rdf:type schema:Periodical
148 sg:person.01174472237.11 schema:affiliation grid-institutes:grid.4989.c
149 schema:familyName Lheureux
150 schema:givenName M.
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174472237.11
152 rdf:type schema:Person
153 sg:person.0632561176.75 schema:affiliation grid-institutes:grid.4989.c
154 schema:familyName Pays
155 schema:givenName E.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632561176.75
157 rdf:type schema:Person
158 sg:person.0723207553.85 schema:affiliation grid-institutes:grid.4989.c
159 schema:familyName Steinert
160 schema:givenName M.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723207553.85
162 rdf:type schema:Person
163 sg:pub.10.1038/273613a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026570145
164 https://doi.org/10.1038/273613a0
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/284078a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004894984
167 https://doi.org/10.1038/284078a0
168 rdf:type schema:CreativeWork
169 grid-institutes:grid.4989.c schema:alternateName Département de Biologie Moléculaire, Université libre de Bruxelles, 67, rue des Chevaux, 1640, Rhode St Genèse, Belgium
170 schema:name Département de Biologie Moléculaire, Université libre de Bruxelles, 67, rue des Chevaux, 1640, Rhode St Genèse, Belgium
171 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...