Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-06

AUTHORS

Hannelore Schnell, Hans G. Zachau, Josef Höchtl, Michael Pech

ABSTRACT

Several mechanisms contribute to the generation of an antibody repertoire (for reviews see refs 1–3) which has been estimated to exceed 106 different types of immunoglobulin molecules4. It is clear that the germ line contains a fair number of V-gene segments2,5–7. The V-gene segments are joined by somatic recombination to J- and D-gene segments8–11 and there is, of course, combinatorial association of heavy and light chains. It has been suggested that the germ-line repertoire of gene segments and their combinatorial joining are the principal sources of antibody diversity12. In fact, two rearranged Vκ-gene segments have been found to be identical in sequence to their germ-line counterparts12,13, showing that no somatic point mutations had occurred. In the genes for a λI light chain14 and for two heavy chains10,15, on the other hand, the rearranged V-gene segments differed in several positions from their germ-line equivalents; this is explained by somatic point mutations. We now report the finding of six single-base pair differences each between two rearranged Vκ-gene segments and their presumptive germ-line equivalents and the absence of any such differences in the adjacent non-coding regions; this suggests the existence of localized mutation mechanism(s) in this Vκ gene system. More... »

PAGES

668

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/291668a0

DOI

http://dx.doi.org/10.1038/291668a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008890303

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6264318


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