Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-05

AUTHORS

Brigid L. M. Hogan, Amanda Taylor, Eileen Adamson

ABSTRACT

F9 is a clonal line of mouse teratocarcinoma-derived embryonal carcinoma (EC) cells which shows very little spontaneous differentiation in vivo or in vitro1. Recently, however, it was reported2–6 that F9 monolayers treated with retinoic acid and dibutyryl cyclic AMP differentiate into an early embryonic cell type known as parietal endoderm, which is one of two distinct populations of extra-embryonic endoderm that differentiate in the normal mouse embryo shortly after implantation7,8. The other population is the visceral endoderm, and the two differ not only in their morphology and location within the embryo, but also in their biochemical properties9–12. Parietal endoderm cells, for example, do not synthesize α-fetoprotein13 (AFP), whereas visceral endoderm cells do13. There is evidence8 that during embryogenesis parietal and visceral endoderm are derived from a common precursor population known as the primary endoderm, and recent experiments with cultured mouse embryos14 suggest that the phenotype of these cells can be modulated by contact with different embryonic tissues. We now show that if F9 EC cultures are treated with retinoic acid when they are in the form of small aggregates, they differentiate on the outer surface cells which morphologically resemble visceral rather than parietal endoderm. In addition, the cells synthesize and secrete AFP, identified by immunoprecipitation and immunoperoxidase reactions using specific anti-AFP immunoglobulin. One interpretation of this result is that F9 cells treated with retinoic acid differentiate first into multipotent cells analogous to the primary endoderm of the normal embryo which then express either the mature parietal or visceral phenotype depending on the nature of the intercellular contact signals they receive. We therefore believe that F9 EC cells may be even more useful than previously supposed for biochemical studies on factors controlling gene expression during mammalian embryogenesis. More... »

PAGES

235-237

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/291235a0

DOI

http://dx.doi.org/10.1038/291235a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023425892

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6164928


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bucladesine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Aggregation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clone Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Teratoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tretinoin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha-Fetoproteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Imperial Cancer Research Fund, Mill Hill Laboratories, Burtonhole Lane, NW7 1AD, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Imperial Cancer Research Fund, Mill Hill Laboratories, Burtonhole Lane, NW7 1AD, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hogan", 
        "givenName": "Brigid L. M.", 
        "id": "sg:person.010060100317.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010060100317.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial Cancer Research Fund, Mill Hill Laboratories, Burtonhole Lane, NW7 1AD, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Imperial Cancer Research Fund, Mill Hill Laboratories, Burtonhole Lane, NW7 1AD, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "Amanda", 
        "id": "sg:person.01306121143.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306121143.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Zoology, University of Oxford, South Parks Road, OX1 2JD, Oxford, UK", 
          "id": "http://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Department of Zoology, University of Oxford, South Parks Road, OX1 2JD, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adamson", 
        "givenName": "Eileen", 
        "id": "sg:person.01034452734.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034452734.65"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/227680a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010419937", 
          "https://doi.org/10.1038/227680a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00569266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027503689", 
          "https://doi.org/10.1007/bf00569266"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1981-05", 
    "datePublishedReg": "1981-05-01", 
    "description": "F9 is a clonal line of mouse teratocarcinoma-derived embryonal carcinoma (EC) cells which shows very little spontaneous differentiation in vivo or in vitro1. Recently, however, it was reported2\u20136 that F9 monolayers treated with retinoic acid and dibutyryl cyclic AMP differentiate into an early embryonic cell type known as parietal endoderm, which is one of two distinct populations of extra-embryonic endoderm that differentiate in the normal mouse embryo shortly after implantation7,8. The other population is the visceral endoderm, and the two differ not only in their morphology and location within the embryo, but also in their biochemical properties9\u201312. Parietal endoderm cells, for example, do not synthesize \u03b1-fetoprotein13 (AFP), whereas visceral endoderm cells do13. There is evidence8 that during embryogenesis parietal and visceral endoderm are derived from a common precursor population known as the primary endoderm, and recent experiments with cultured mouse embryos14 suggest that the phenotype of these cells can be modulated by contact with different embryonic tissues. We now show that if F9 EC cultures are treated with retinoic acid when they are in the form of small aggregates, they differentiate on the outer surface cells which morphologically resemble visceral rather than parietal endoderm. In addition, the cells synthesize and secrete AFP, identified by immunoprecipitation and immunoperoxidase reactions using specific anti-AFP immunoglobulin. One interpretation of this result is that F9 cells treated with retinoic acid differentiate first into multipotent cells analogous to the primary endoderm of the normal embryo which then express either the mature parietal or visceral phenotype depending on the nature of the intercellular contact signals they receive. We therefore believe that F9 EC cells may be even more useful than previously supposed for biochemical studies on factors controlling gene expression during mammalian embryogenesis.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/291235a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5812", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "291"
      }
    ], 
    "keywords": [
      "visceral endoderm", 
      "primary endoderm", 
      "parietal endoderm", 
      "retinoic acid differentiate", 
      "embryonic cell types", 
      "different embryonic tissues", 
      "embryonal carcinoma cell differentiation", 
      "extra-embryonic endoderm", 
      "parietal endoderm cells", 
      "carcinoma cell differentiation", 
      "common precursor population", 
      "embryonal carcinoma cells", 
      "retinoic acid", 
      "mammalian embryogenesis", 
      "normal mouse embryos", 
      "F9 EC cells", 
      "endoderm cells", 
      "F9 cells", 
      "mouse embryos", 
      "gene expression", 
      "endoderm", 
      "embryonic tissues", 
      "spontaneous differentiation", 
      "multipotent cells", 
      "cell differentiation", 
      "cell types", 
      "biochemical studies", 
      "clonal lines", 
      "precursor population", 
      "distinct populations", 
      "acid differentiates", 
      "embryos", 
      "embryogenesis", 
      "normal embryos", 
      "EC cells", 
      "cell interactions", 
      "carcinoma cells", 
      "contact signals", 
      "phenotype", 
      "cells", 
      "EC cultures", 
      "differentiation", 
      "cyclic AMP", 
      "dibutyryl cyclic AMP", 
      "immunoprecipitation", 
      "surface cells", 
      "small aggregates", 
      "population", 
      "visceral phenotype", 
      "differentiates", 
      "acid", 
      "F9", 
      "expression", 
      "Vitro1", 
      "vivo", 
      "tissue", 
      "AMP", 
      "lines", 
      "interaction", 
      "recent experiments", 
      "culture", 
      "aggregates", 
      "morphology", 
      "signals", 
      "addition", 
      "factors", 
      "monolayers", 
      "types", 
      "form", 
      "location", 
      "experiments", 
      "immunoglobulin", 
      "study", 
      "contact", 
      "immunoperoxidase reaction", 
      "nature", 
      "results", 
      "reaction", 
      "AFP", 
      "example", 
      "interpretation"
    ], 
    "name": "Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm", 
    "pagination": "235-237", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023425892"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/291235a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6164928"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/291235a0", 
      "https://app.dimensions.ai/details/publication/pub.1023425892"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T21:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_160.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/291235a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/291235a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/291235a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/291235a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/291235a0'


 

This table displays all metadata directly associated to this object as RDF triples.

215 TRIPLES      21 PREDICATES      121 URIs      110 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/291235a0 schema:about N0b1221369eb8412cafc46f6d44a96d14
2 N157e36bc5d2d4ca2b9ca492df669d743
3 N2a15d163c3f94b78a312e18d9ca2f31d
4 N2b35f71e9cc94032947db15621bd609c
5 N31597d0b462c44f1ad5405fb915dfb60
6 N4543036923c44c499dde8b7129fab384
7 N535553486a50469db139faae8544ee73
8 N6510c5d9f3ad4fcaaddb8e3d7dbe2fc6
9 N866ea34a6dc54cafbd81a9838aa6b73f
10 N88589d5fdb8a47a994609c7aad75dbbd
11 Naf31271c6d2b4223a1a76448cb5fe602
12 anzsrc-for:06
13 anzsrc-for:0601
14 anzsrc-for:0604
15 schema:author Nbc5c16c6ca704f9a884efa0ecc5e7e08
16 schema:citation sg:pub.10.1007/bf00569266
17 sg:pub.10.1038/227680a0
18 schema:datePublished 1981-05
19 schema:datePublishedReg 1981-05-01
20 schema:description F9 is a clonal line of mouse teratocarcinoma-derived embryonal carcinoma (EC) cells which shows very little spontaneous differentiation in vivo or in vitro1. Recently, however, it was reported2–6 that F9 monolayers treated with retinoic acid and dibutyryl cyclic AMP differentiate into an early embryonic cell type known as parietal endoderm, which is one of two distinct populations of extra-embryonic endoderm that differentiate in the normal mouse embryo shortly after implantation7,8. The other population is the visceral endoderm, and the two differ not only in their morphology and location within the embryo, but also in their biochemical properties9–12. Parietal endoderm cells, for example, do not synthesize α-fetoprotein13 (AFP), whereas visceral endoderm cells do13. There is evidence8 that during embryogenesis parietal and visceral endoderm are derived from a common precursor population known as the primary endoderm, and recent experiments with cultured mouse embryos14 suggest that the phenotype of these cells can be modulated by contact with different embryonic tissues. We now show that if F9 EC cultures are treated with retinoic acid when they are in the form of small aggregates, they differentiate on the outer surface cells which morphologically resemble visceral rather than parietal endoderm. In addition, the cells synthesize and secrete AFP, identified by immunoprecipitation and immunoperoxidase reactions using specific anti-AFP immunoglobulin. One interpretation of this result is that F9 cells treated with retinoic acid differentiate first into multipotent cells analogous to the primary endoderm of the normal embryo which then express either the mature parietal or visceral phenotype depending on the nature of the intercellular contact signals they receive. We therefore believe that F9 EC cells may be even more useful than previously supposed for biochemical studies on factors controlling gene expression during mammalian embryogenesis.
21 schema:genre article
22 schema:isAccessibleForFree false
23 schema:isPartOf N9f2d9d96258848519bc6a6d4b18a35ad
24 Nd2b2c9b2b55c443aa755f690f778140c
25 sg:journal.1018957
26 schema:keywords AFP
27 AMP
28 EC cells
29 EC cultures
30 F9
31 F9 EC cells
32 F9 cells
33 Vitro1
34 acid
35 acid differentiates
36 addition
37 aggregates
38 biochemical studies
39 carcinoma cell differentiation
40 carcinoma cells
41 cell differentiation
42 cell interactions
43 cell types
44 cells
45 clonal lines
46 common precursor population
47 contact
48 contact signals
49 culture
50 cyclic AMP
51 dibutyryl cyclic AMP
52 different embryonic tissues
53 differentiates
54 differentiation
55 distinct populations
56 embryogenesis
57 embryonal carcinoma cell differentiation
58 embryonal carcinoma cells
59 embryonic cell types
60 embryonic tissues
61 embryos
62 endoderm
63 endoderm cells
64 example
65 experiments
66 expression
67 extra-embryonic endoderm
68 factors
69 form
70 gene expression
71 immunoglobulin
72 immunoperoxidase reaction
73 immunoprecipitation
74 interaction
75 interpretation
76 lines
77 location
78 mammalian embryogenesis
79 monolayers
80 morphology
81 mouse embryos
82 multipotent cells
83 nature
84 normal embryos
85 normal mouse embryos
86 parietal endoderm
87 parietal endoderm cells
88 phenotype
89 population
90 precursor population
91 primary endoderm
92 reaction
93 recent experiments
94 results
95 retinoic acid
96 retinoic acid differentiate
97 signals
98 small aggregates
99 spontaneous differentiation
100 study
101 surface cells
102 tissue
103 types
104 visceral endoderm
105 visceral phenotype
106 vivo
107 schema:name Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm
108 schema:pagination 235-237
109 schema:productId N92b2a79ef29e474b9eae395df1f4bed5
110 Ncc1e2dfa014e4de3b6210c95e774e4f0
111 Nf0a146febbe24828b6a5c0205fc2d4b8
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023425892
113 https://doi.org/10.1038/291235a0
114 schema:sdDatePublished 2022-06-01T21:58
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher Ne89e4d8e689a4ae7a65e89c3debe00c6
117 schema:url https://doi.org/10.1038/291235a0
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N0b1221369eb8412cafc46f6d44a96d14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cell Line
123 rdf:type schema:DefinedTerm
124 N157e36bc5d2d4ca2b9ca492df669d743 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Cell Differentiation
126 rdf:type schema:DefinedTerm
127 N2a15d163c3f94b78a312e18d9ca2f31d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Animals
129 rdf:type schema:DefinedTerm
130 N2b35f71e9cc94032947db15621bd609c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Tretinoin
132 rdf:type schema:DefinedTerm
133 N2d19a15bfcb9457e81e7c2f0777110ee rdf:first sg:person.01034452734.65
134 rdf:rest rdf:nil
135 N31597d0b462c44f1ad5405fb915dfb60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Mice
137 rdf:type schema:DefinedTerm
138 N4543036923c44c499dde8b7129fab384 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Clone Cells
140 rdf:type schema:DefinedTerm
141 N535553486a50469db139faae8544ee73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Teratoma
143 rdf:type schema:DefinedTerm
144 N6510c5d9f3ad4fcaaddb8e3d7dbe2fc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Embryo, Mammalian
146 rdf:type schema:DefinedTerm
147 N866ea34a6dc54cafbd81a9838aa6b73f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Bucladesine
149 rdf:type schema:DefinedTerm
150 N88589d5fdb8a47a994609c7aad75dbbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cell Aggregation
152 rdf:type schema:DefinedTerm
153 N92b2a79ef29e474b9eae395df1f4bed5 schema:name doi
154 schema:value 10.1038/291235a0
155 rdf:type schema:PropertyValue
156 N9f2d9d96258848519bc6a6d4b18a35ad schema:issueNumber 5812
157 rdf:type schema:PublicationIssue
158 Naf31271c6d2b4223a1a76448cb5fe602 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name alpha-Fetoproteins
160 rdf:type schema:DefinedTerm
161 Nbc5c16c6ca704f9a884efa0ecc5e7e08 rdf:first sg:person.010060100317.01
162 rdf:rest Nfbaa86a221fa44d1b03d404d15645b45
163 Ncc1e2dfa014e4de3b6210c95e774e4f0 schema:name pubmed_id
164 schema:value 6164928
165 rdf:type schema:PropertyValue
166 Nd2b2c9b2b55c443aa755f690f778140c schema:volumeNumber 291
167 rdf:type schema:PublicationVolume
168 Ne89e4d8e689a4ae7a65e89c3debe00c6 schema:name Springer Nature - SN SciGraph project
169 rdf:type schema:Organization
170 Nf0a146febbe24828b6a5c0205fc2d4b8 schema:name dimensions_id
171 schema:value pub.1023425892
172 rdf:type schema:PropertyValue
173 Nfbaa86a221fa44d1b03d404d15645b45 rdf:first sg:person.01306121143.73
174 rdf:rest N2d19a15bfcb9457e81e7c2f0777110ee
175 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
176 schema:name Biological Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biochemistry and Cell Biology
180 rdf:type schema:DefinedTerm
181 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
182 schema:name Genetics
183 rdf:type schema:DefinedTerm
184 sg:journal.1018957 schema:issn 0028-0836
185 1476-4687
186 schema:name Nature
187 schema:publisher Springer Nature
188 rdf:type schema:Periodical
189 sg:person.010060100317.01 schema:affiliation grid-institutes:grid.11485.39
190 schema:familyName Hogan
191 schema:givenName Brigid L. M.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010060100317.01
193 rdf:type schema:Person
194 sg:person.01034452734.65 schema:affiliation grid-institutes:grid.4991.5
195 schema:familyName Adamson
196 schema:givenName Eileen
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034452734.65
198 rdf:type schema:Person
199 sg:person.01306121143.73 schema:affiliation grid-institutes:grid.11485.39
200 schema:familyName Taylor
201 schema:givenName Amanda
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306121143.73
203 rdf:type schema:Person
204 sg:pub.10.1007/bf00569266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027503689
205 https://doi.org/10.1007/bf00569266
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/227680a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010419937
208 https://doi.org/10.1038/227680a0
209 rdf:type schema:CreativeWork
210 grid-institutes:grid.11485.39 schema:alternateName Imperial Cancer Research Fund, Mill Hill Laboratories, Burtonhole Lane, NW7 1AD, London, UK
211 schema:name Imperial Cancer Research Fund, Mill Hill Laboratories, Burtonhole Lane, NW7 1AD, London, UK
212 rdf:type schema:Organization
213 grid-institutes:grid.4991.5 schema:alternateName Department of Zoology, University of Oxford, South Parks Road, OX1 2JD, Oxford, UK
214 schema:name Department of Zoology, University of Oxford, South Parks Road, OX1 2JD, Oxford, UK
215 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...