IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-05

AUTHORS

Patricia J. Gearhart, Nelson D. Johnson, Richard Douglas, Leroy Hood

ABSTRACT

An amino acid sequence analysis of the N-terminal immunoglobulin heavy and light chain variable regions (VH and VL) from 16 hybridoma proteins which bind phosphorylcholine as well as the complete sequence analysis of 9 of these VH regions is presented. There seem to be more VH regions participating in the phosphorylcholine response than can be encoded directly by germ-line VH gene segments. Moreover, the V regions from IgG antibodies are considerably more variable than those from their IgM counterparts. These observations raise the possibility that a somatic mechanism for V region diversification produces greater diversity in IgG than in IgM antibodies. More... »

PAGES

29-34

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/291029a0

DOI

http://dx.doi.org/10.1038/291029a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038626934

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7231520


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/291029a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/291029a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/291029a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/291029a0'


 

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