Sequential functions of the bithorax complex of Drosophila View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-04

AUTHORS

Gines Morata, Stephen Kerridge

ABSTRACT

The bithorax genes are a group of homoeotic genes of Drosophila whose function is related to the control of segment development. They form a gene complex in which at least seven different loci have been identified. Mutations at each of these loci produce a specific homoeotic transformation whereby a segment is transformed either in part or completely into another. In embryos completely deficient for the bithorax genes, all the thoracic and abdominal segments resemble mesothoracic segments. This observation, together with the segmental specificity of the mutant phenotypes, led Lewis to suggest a model of genetic control in which the type of development in each segment is specified by the activation of a fraction of the total number of bithorax genes. Thus, lack of activity of the bithorax genes results in mesothoracic development, activation of the bithorax (bx+) and postbithorax (pbx+) genes produces metathorax (anterior and posterior respectively), and activation of these two genes with bithoraxoid (bxd+) produces the first abdominal segment and so on. Although this model explains the genetic and developmental data, it leaves unexplained formation of the prothoracic segment. We now describe two unexpected results: deficiencies for bithorax genes can lead to segments being transformed into prothorax, and there is a temporal sequence in the function of the bithorax system. More... »

PAGES

778

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/290778a0

DOI

http://dx.doi.org/10.1038/290778a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047952210

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7219563


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blastoderm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Regulator", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thorax", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Morata", 
        "givenName": "Gines", 
        "id": "sg:person.0726450737.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726450737.59"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kerridge", 
        "givenName": "Stephen", 
        "id": "sg:person.0774564137.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774564137.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0012-1606(75)90330-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001410071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/276565a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009007731", 
          "https://doi.org/10.1038/276565a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(77)90153-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014424651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00848298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018364737", 
          "https://doi.org/10.1007/bf00848298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(76)90052-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031065118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(65)90037-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044652668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/icb/3.1.33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059653384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077357788", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080112586", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1981-04", 
    "datePublishedReg": "1981-04-01", 
    "description": "The bithorax genes are a group of homoeotic genes of Drosophila whose function is related to the control of segment development. They form a gene complex in which at least seven different loci have been identified. Mutations at each of these loci produce a specific homoeotic transformation whereby a segment is transformed either in part or completely into another. In embryos completely deficient for the bithorax genes, all the thoracic and abdominal segments resemble mesothoracic segments. This observation, together with the segmental specificity of the mutant phenotypes, led Lewis to suggest a model of genetic control in which the type of development in each segment is specified by the activation of a fraction of the total number of bithorax genes. Thus, lack of activity of the bithorax genes results in mesothoracic development, activation of the bithorax (bx+) and postbithorax (pbx+) genes produces metathorax (anterior and posterior respectively), and activation of these two genes with bithoraxoid (bxd+) produces the first abdominal segment and so on. Although this model explains the genetic and developmental data, it leaves unexplained formation of the prothoracic segment. We now describe two unexpected results: deficiencies for bithorax genes can lead to segments being transformed into prothorax, and there is a temporal sequence in the function of the bithorax system.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/290778a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5809", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "290"
      }
    ], 
    "name": "Sequential functions of the bithorax complex of Drosophila", 
    "pagination": "778", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e46eebb887d617d4f4e1f13eb1430773239990fde85a5841a3ee573d68deda1b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7219563"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/290778a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047952210"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/290778a0", 
      "https://app.dimensions.ai/details/publication/pub.1047952210"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/290778a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/290778a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/290778a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/290778a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/290778a0'


 

This table displays all metadata directly associated to this object as RDF triples.

130 TRIPLES      21 PREDICATES      46 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/290778a0 schema:about N2f23e3b9ead54658aa41768cf0213ce2
2 N32b38a2423324c26a587bef278d873e2
3 N3c1ea8a57ad94f62a2816aa582dce140
4 N9cfadefa0a24440db9e06526f178a2ce
5 Na533e66b31bf4b88b1ab12b4b06dbece
6 Nafcbb386de364d2a8172c1266858eaff
7 Nd89e13041fed42a9b27fb8f033dd6ed6
8 Nedf04e4695634687ad53111dc920a9bc
9 anzsrc-for:06
10 anzsrc-for:0604
11 schema:author N86c315749d2b4d61aff3570dc5d0ee70
12 schema:citation sg:pub.10.1007/bf00848298
13 sg:pub.10.1038/276565a0
14 https://app.dimensions.ai/details/publication/pub.1077357788
15 https://app.dimensions.ai/details/publication/pub.1080112586
16 https://doi.org/10.1016/0012-1606(65)90037-0
17 https://doi.org/10.1016/0012-1606(75)90330-9
18 https://doi.org/10.1016/0012-1606(76)90052-x
19 https://doi.org/10.1016/0012-1606(77)90153-1
20 https://doi.org/10.1093/icb/3.1.33
21 schema:datePublished 1981-04
22 schema:datePublishedReg 1981-04-01
23 schema:description The bithorax genes are a group of homoeotic genes of Drosophila whose function is related to the control of segment development. They form a gene complex in which at least seven different loci have been identified. Mutations at each of these loci produce a specific homoeotic transformation whereby a segment is transformed either in part or completely into another. In embryos completely deficient for the bithorax genes, all the thoracic and abdominal segments resemble mesothoracic segments. This observation, together with the segmental specificity of the mutant phenotypes, led Lewis to suggest a model of genetic control in which the type of development in each segment is specified by the activation of a fraction of the total number of bithorax genes. Thus, lack of activity of the bithorax genes results in mesothoracic development, activation of the bithorax (bx+) and postbithorax (pbx+) genes produces metathorax (anterior and posterior respectively), and activation of these two genes with bithoraxoid (bxd+) produces the first abdominal segment and so on. Although this model explains the genetic and developmental data, it leaves unexplained formation of the prothoracic segment. We now describe two unexpected results: deficiencies for bithorax genes can lead to segments being transformed into prothorax, and there is a temporal sequence in the function of the bithorax system.
24 schema:genre research_article
25 schema:inLanguage en
26 schema:isAccessibleForFree false
27 schema:isPartOf N832c3299bd3544bfa783c80d901faa08
28 Nf1ef4df49cb54dfcbe25688fd32af459
29 sg:journal.1018957
30 schema:name Sequential functions of the bithorax complex of Drosophila
31 schema:pagination 778
32 schema:productId N185541e6150546d2ae551ecd9ef87a1e
33 N1a1a028392804ae5a1e5243ab14b7f9e
34 N751027375e5b462bad6164ef56f114fe
35 N967630b8e0ab4f0e97ccff77bb629f4e
36 Nb42d149f5e464685b049f0dceac547cb
37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047952210
38 https://doi.org/10.1038/290778a0
39 schema:sdDatePublished 2019-04-11T00:04
40 schema:sdLicense https://scigraph.springernature.com/explorer/license/
41 schema:sdPublisher N7e16dbdabdd94399a0d7b061b7701a05
42 schema:url https://www.nature.com/articles/290778a0
43 sgo:license sg:explorer/license/
44 sgo:sdDataset articles
45 rdf:type schema:ScholarlyArticle
46 N185541e6150546d2ae551ecd9ef87a1e schema:name doi
47 schema:value 10.1038/290778a0
48 rdf:type schema:PropertyValue
49 N1a1a028392804ae5a1e5243ab14b7f9e schema:name dimensions_id
50 schema:value pub.1047952210
51 rdf:type schema:PropertyValue
52 N2f23e3b9ead54658aa41768cf0213ce2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
53 schema:name Genes
54 rdf:type schema:DefinedTerm
55 N32b38a2423324c26a587bef278d873e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Blastoderm
57 rdf:type schema:DefinedTerm
58 N3c1ea8a57ad94f62a2816aa582dce140 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Drosophila
60 rdf:type schema:DefinedTerm
61 N751027375e5b462bad6164ef56f114fe schema:name nlm_unique_id
62 schema:value 0410462
63 rdf:type schema:PropertyValue
64 N7e16dbdabdd94399a0d7b061b7701a05 schema:name Springer Nature - SN SciGraph project
65 rdf:type schema:Organization
66 N832c3299bd3544bfa783c80d901faa08 schema:volumeNumber 290
67 rdf:type schema:PublicationVolume
68 N86c315749d2b4d61aff3570dc5d0ee70 rdf:first sg:person.0726450737.59
69 rdf:rest Nf3b70594836a4225be9c41a33d64651d
70 N967630b8e0ab4f0e97ccff77bb629f4e schema:name pubmed_id
71 schema:value 7219563
72 rdf:type schema:PropertyValue
73 N9cfadefa0a24440db9e06526f178a2ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Animals
75 rdf:type schema:DefinedTerm
76 Na533e66b31bf4b88b1ab12b4b06dbece schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Time Factors
78 rdf:type schema:DefinedTerm
79 Nafcbb386de364d2a8172c1266858eaff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Thorax
81 rdf:type schema:DefinedTerm
82 Nb42d149f5e464685b049f0dceac547cb schema:name readcube_id
83 schema:value e46eebb887d617d4f4e1f13eb1430773239990fde85a5841a3ee573d68deda1b
84 rdf:type schema:PropertyValue
85 Nd89e13041fed42a9b27fb8f033dd6ed6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Genes, Regulator
87 rdf:type schema:DefinedTerm
88 Nedf04e4695634687ad53111dc920a9bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Mutation
90 rdf:type schema:DefinedTerm
91 Nf1ef4df49cb54dfcbe25688fd32af459 schema:issueNumber 5809
92 rdf:type schema:PublicationIssue
93 Nf3b70594836a4225be9c41a33d64651d rdf:first sg:person.0774564137.31
94 rdf:rest rdf:nil
95 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
96 schema:name Biological Sciences
97 rdf:type schema:DefinedTerm
98 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
99 schema:name Genetics
100 rdf:type schema:DefinedTerm
101 sg:journal.1018957 schema:issn 0090-0028
102 1476-4687
103 schema:name Nature
104 rdf:type schema:Periodical
105 sg:person.0726450737.59 schema:familyName Morata
106 schema:givenName Gines
107 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726450737.59
108 rdf:type schema:Person
109 sg:person.0774564137.31 schema:familyName Kerridge
110 schema:givenName Stephen
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774564137.31
112 rdf:type schema:Person
113 sg:pub.10.1007/bf00848298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018364737
114 https://doi.org/10.1007/bf00848298
115 rdf:type schema:CreativeWork
116 sg:pub.10.1038/276565a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009007731
117 https://doi.org/10.1038/276565a0
118 rdf:type schema:CreativeWork
119 https://app.dimensions.ai/details/publication/pub.1077357788 schema:CreativeWork
120 https://app.dimensions.ai/details/publication/pub.1080112586 schema:CreativeWork
121 https://doi.org/10.1016/0012-1606(65)90037-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044652668
122 rdf:type schema:CreativeWork
123 https://doi.org/10.1016/0012-1606(75)90330-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001410071
124 rdf:type schema:CreativeWork
125 https://doi.org/10.1016/0012-1606(76)90052-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031065118
126 rdf:type schema:CreativeWork
127 https://doi.org/10.1016/0012-1606(77)90153-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014424651
128 rdf:type schema:CreativeWork
129 https://doi.org/10.1093/icb/3.1.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059653384
130 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...