Left-handed DNA in restriction fragments and a recombinant plasmid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-04

AUTHORS

Jan Kłysik, Steven M. Stirdivant, Jacquelynn E. Larson, Phillip A. Hart, Robert D. Wells

ABSTRACT

Circular dichroism and 31P-NMR on synthetic oligomers of (dC-dG) inserted within DNA restriction fragments indicate that the right-handed B-structure can exist in close proximity to the left-handed Z-structure. Also, this salt-induced transition to Z-form in a small (dC-dG) segment (1.3%) of a recombinant plasmid markedly influenced the supercoil of the plasmid. These observations have implications for the postulated role of naturally occurring related simple sequences in the regulation of gene activity. More... »

PAGES

672-677

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/290672a0

DOI

http://dx.doi.org/10.1038/290672a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023183731

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6261149


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