Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-04

AUTHORS

Yoshikazu Kurosawa, Harald von Boehmer, Werner Haas, Hitoshi Sakano, André Trauneker, Susumu Tonegawa

ABSTRACT

The finding that the diversity (D) and joining (JH) but not the variable (VH) DNA segments of mouse immunoglobulin heavy-chain genes are joined in the DNA of some cloned cytolytic T cells, led to identification and sequencing of three different D DNA segments. Two segments identified on the embryo DNA carry on both the 5′ and 3′ sides two sets of characteristic sequences separated by a 12-base pair spacer, which have been implicated as recognition signals for a recombinase. The third segment, identified in a form joined with a JHDNA segment in a T cell, carries the recognition signal on the 5′ side. These results support the 12/23-base pair model for somatic generation of immunoglobulin V genes, and rule out the possibility that the cytolytic T cells use assembled VH, D and JH sequences to encode their antigen receptors. More... »

PAGES

565-570

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/290565a0

DOI

http://dx.doi.org/10.1038/290565a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020825524

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6783962


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