Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-04

AUTHORS

Hitoshi Sakano, Yoshikazu Kurosawa, Martin Weigert, Susumu Tonegawa

ABSTRACT

A putative diversity segment of immunoglobulin heavy-chain genes (D segment) has been identified 700 base pairs 5′ to JH1 DNA on the germ-line genome of the mouse. This 10-base pair D segment is flanked by two sets of sequences related towhich are possible recognition sites for a recombinase. The spacer separating the heptamer and the nonamer is 12 base pairs long on both sides of the D segment. As the spacer separating the two signal sequences in VH DNAs and JH DNAs is 23 ± 1 base pairs long, the two recombinations required for creation of a complete immunoglobulin VHgene, a VH–D joining and a D–JH joining, follow a 12/23-base pair spacer rule. Allelic exclusion is discussed with respect to D segments. More... »

PAGES

562-565

References to SciGraph publications

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  • 1979-07. Sequences at the somatic recombination sites of immunoglobulin light-chain genes in NATURE
  • 1980-08. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes in NATURE
  • 1980-01. The role of gene deletion in the immunoglobulin heavy chain switch in NATURE
  • 1980-08. RNA splicing generates a variant light chain from an aberrantly rearranged κ gene in NATURE
  • 1980-10. Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma in NATURE
  • 1980-07. An unusual translocation of immunoglobulin gene segments in variants of the mouse myeloma MPC11 in NATURE
  • 1981-04. Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes in NATURE
  • 1979-08. A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation in NATURE
  • 1979-02. Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments in NATURE
  • 1980-08. Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome in NATURE
  • 1980-06. Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression in NATURE
  • 1980-08. A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/290562a0

    DOI

    http://dx.doi.org/10.1038/290562a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008003271

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6783961


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