Triclosan targets lipid synthesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-08

AUTHORS

Laura M. McMurry, Margret Oethinger, Stuart B. Levy

ABSTRACT

Triclosan is a broad-spectrum antibacterial and antifungal agent1,2, which acts by previously undetermined mechanisms, that is used in products such as antiseptic soaps, toothpastes, fabrics and plastics. Here we show that triclosan blocks lipid synthesis in Escherichia coli, and that mutations in, or overexpression of, the gene fabI (which encodes enoyl reductase, involved in fatty acid synthesis) prevents this blockage. This is, to our knowledge, the first evidence that triclosan acts on a specific bacterial target, rather than as a nonspecific ‘biocide’. More... »

PAGES

531-532

Journal

TITLE

Nature

ISSUE

6693

VOLUME

394

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/28970

DOI

http://dx.doi.org/10.1038/28970

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033736366

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9707111


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