Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-01

AUTHORS

Charles Van Beveren, Janice A. Galleshaw, Vivian Jonas, Anton J. M. Berns, Russell F. Doolittle, Daniel J. Donoghue, Inder M. Verma

ABSTRACT

The complete nucleotide sequence of the transforming gene of a mouse sarcoma virus has been determined. It codes for a protein of 374 amino acids. The nucleotide sequence of the junctions between a murine leukaemia virus and cellular sequences leading to the formation of the viral transforming gene have also been elucidated. The viral transforming sequence and its cellular homologue share an uninterrupted stretch of 1,159 nucleotides, with few base substitutions. The predicted amino acid sequence of the mouse sarcoma virus transforming gene was found to share considerable homology with the proposed amino acid sequence of the avian sarcoma virus oncogene (src) product. More... »

PAGES

258

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/289258a0

DOI

http://dx.doi.org/10.1038/289258a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018787893

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6256659


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58 schema:description The complete nucleotide sequence of the transforming gene of a mouse sarcoma virus has been determined. It codes for a protein of 374 amino acids. The nucleotide sequence of the junctions between a murine leukaemia virus and cellular sequences leading to the formation of the viral transforming gene have also been elucidated. The viral transforming sequence and its cellular homologue share an uninterrupted stretch of 1,159 nucleotides, with few base substitutions. The predicted amino acid sequence of the mouse sarcoma virus transforming gene was found to share considerable homology with the proposed amino acid sequence of the avian sarcoma virus oncogene (src) product.
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