The C1q receptor site on immunoglobulin G View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-11

AUTHORS

D R Burton, J Boyd, A D Brampton, S B Easterbrook-Smith, E J Emanuel, J Novotny, T W Rademacher, M R van Schravendijk, M J Sternberg, R A Dwek

ABSTRACT

We propose that, the binding site for the complement subcomponent Clq on immunoglobulin G involves the last two (C-terminal) beta-strands of the C gamma 2 domain. This region contains a large number of accessible and highly conserved charged residues and charge is postulated as an important component of the Clq-IgG interaction. The conclusions are reached on the basis of accessibility and sequence conservation analyses of C gamma 2 amino acid residues, the use of specific inhibitors and chemical modification studies. More... »

PAGES

338-344

Journal

TITLE

Nature

ISSUE

5789

VOLUME

288

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/288338a0

    DOI

    http://dx.doi.org/10.1038/288338a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037652344

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6776418


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