Sharing of an idiotypic marker by monoclonal antibodies specific for distinct regions of hen lysozyme View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-10

AUTHORS

Dennis W. Metzger, Alexander Miller, Eli E. Sercarz

ABSTRACT

Idiotypes have been defined serologically as variable-region markers present on unique subsets of antibody molecules. Most studies involving myeloma proteins and antibody responses in inbred mice have indicated that idiotypy is closely related to antigenic specificity. However, indirect evidence suggests that idiotypy can sometimes be dissociated from specificity. In the response to the small monomeric protein, hen egg-white lysozyme (HEL), previous results demonstrated that 70--95% of the anti-HEL antibody found in sera of primed and boosted mice is specific for a particular region of HEL and bears a predominant idiotype (IdX-HEL). In this report, hybridoma anti-HEL antibodies tested with well-characterized peptide fragments of HEL show that the IdX-HEL marker can be found on antibodies of completely distinct antigen specificities. Thus, a mode of recognition other than antigenic recognition probably plays a major role in the immune response to HEL. More... »

PAGES

540

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/287540a0

DOI

http://dx.doi.org/10.1038/287540a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022071545

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6158685


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chickens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clone Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epitopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Idiotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunologic Memory", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Cooperation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muramidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Metzger", 
        "givenName": "Dennis W.", 
        "id": "sg:person.0616307541.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616307541.57"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Miller", 
        "givenName": "Alexander", 
        "id": "sg:person.01065517405.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065517405.85"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Sercarz", 
        "givenName": "Eli E.", 
        "id": "sg:person.01141524574.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141524574.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/281594a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009169346", 
          "https://doi.org/10.1038/281594a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.148.6.1488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013338384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0161-5890(79)90044-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018037696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0161-5890(79)90044-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018037696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830091113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019758731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.144.5.1254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024011231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(73)80139-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031360817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.68.10.2616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040269847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.146.5.1436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046229624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.130.3.619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048041155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082338542", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1980-10", 
    "datePublishedReg": "1980-10-01", 
    "description": "Idiotypes have been defined serologically as variable-region markers present on unique subsets of antibody molecules. Most studies involving myeloma proteins and antibody responses in inbred mice have indicated that idiotypy is closely related to antigenic specificity. However, indirect evidence suggests that idiotypy can sometimes be dissociated from specificity. In the response to the small monomeric protein, hen egg-white lysozyme (HEL), previous results demonstrated that 70--95% of the anti-HEL antibody found in sera of primed and boosted mice is specific for a particular region of HEL and bears a predominant idiotype (IdX-HEL). In this report, hybridoma anti-HEL antibodies tested with well-characterized peptide fragments of HEL show that the IdX-HEL marker can be found on antibodies of completely distinct antigen specificities. Thus, a mode of recognition other than antigenic recognition probably plays a major role in the immune response to HEL.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/287540a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2466371", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2682469", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2449296", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634192", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5782", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "287"
      }
    ], 
    "name": "Sharing of an idiotypic marker by monoclonal antibodies specific for distinct regions of hen lysozyme", 
    "pagination": "540", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6927838e8be7e71b80455685da4856b6c6e8fb39774c6471057a40ec98de4e82"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6158685"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/287540a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022071545"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/287540a0", 
      "https://app.dimensions.ai/details/publication/pub.1022071545"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/287540a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/287540a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/287540a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/287540a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/287540a0'


 

This table displays all metadata directly associated to this object as RDF triples.

167 TRIPLES      21 PREDICATES      52 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/287540a0 schema:about N1db3188b710a46ce9df4e182db362530
2 N28ad8887698f4278bc8f805004a1a1e4
3 N31ef3e795f6d45fe9b08c287fb8c6b96
4 N4905b9e9cf274044b74f0533bf055cca
5 N522d521727fe4497bd3f924ae57b5e51
6 N666e83ceff244319905516f960a3c39f
7 N7d1e6b4fa1444e7d88f0cd6bfad2a2ec
8 N8d687eb44b2f4206a9f24dcc5e21d317
9 N9932d93a87fe4be9bd71f60a60f69aea
10 Nb772b58fdbdb4242a70b805ef5c70822
11 Nbe4720784c1d4780aa383bdde550543c
12 Ne1d3909fca7c4856876889dce3f04d96
13 Nf6997efa49cb44559e4f4343deef9326
14 anzsrc-for:11
15 anzsrc-for:1107
16 schema:author N3e900c463a04437f9f299eae97e0023a
17 schema:citation sg:pub.10.1038/281594a0
18 https://app.dimensions.ai/details/publication/pub.1082338542
19 https://doi.org/10.1002/eji.1830091113
20 https://doi.org/10.1016/0014-5793(73)80139-5
21 https://doi.org/10.1016/0161-5890(79)90044-0
22 https://doi.org/10.1073/pnas.68.10.2616
23 https://doi.org/10.1084/jem.130.3.619
24 https://doi.org/10.1084/jem.144.5.1254
25 https://doi.org/10.1084/jem.146.5.1436
26 https://doi.org/10.1084/jem.148.6.1488
27 schema:datePublished 1980-10
28 schema:datePublishedReg 1980-10-01
29 schema:description Idiotypes have been defined serologically as variable-region markers present on unique subsets of antibody molecules. Most studies involving myeloma proteins and antibody responses in inbred mice have indicated that idiotypy is closely related to antigenic specificity. However, indirect evidence suggests that idiotypy can sometimes be dissociated from specificity. In the response to the small monomeric protein, hen egg-white lysozyme (HEL), previous results demonstrated that 70--95% of the anti-HEL antibody found in sera of primed and boosted mice is specific for a particular region of HEL and bears a predominant idiotype (IdX-HEL). In this report, hybridoma anti-HEL antibodies tested with well-characterized peptide fragments of HEL show that the IdX-HEL marker can be found on antibodies of completely distinct antigen specificities. Thus, a mode of recognition other than antigenic recognition probably plays a major role in the immune response to HEL.
30 schema:genre research_article
31 schema:inLanguage en
32 schema:isAccessibleForFree false
33 schema:isPartOf N261460a60e30426587d17e9a5bc1c589
34 Ndca1e3ae6d2c47b1ac6f8c5d56fb106e
35 sg:journal.1018957
36 schema:name Sharing of an idiotypic marker by monoclonal antibodies specific for distinct regions of hen lysozyme
37 schema:pagination 540
38 schema:productId N20a73644c07d467e891e3f226fcf65bc
39 N464809203e834335b4af993c30790525
40 N786af2b3b8e1466397753a5d73e44bbf
41 N7e050cd32f0a4128a199b7783b7338f6
42 Ne791a12e098e4da48e9d70294e57b3a9
43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022071545
44 https://doi.org/10.1038/287540a0
45 schema:sdDatePublished 2019-04-10T14:47
46 schema:sdLicense https://scigraph.springernature.com/explorer/license/
47 schema:sdPublisher Ne4c34cb0ba6b46b7b1cfd4d3e9459483
48 schema:url https://www.nature.com/articles/287540a0
49 sgo:license sg:explorer/license/
50 sgo:sdDataset articles
51 rdf:type schema:ScholarlyArticle
52 N080da0e7b36a4e228b7323e65459a0ca rdf:first sg:person.01141524574.77
53 rdf:rest rdf:nil
54 N1db3188b710a46ce9df4e182db362530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
55 schema:name T-Lymphocytes
56 rdf:type schema:DefinedTerm
57 N20a73644c07d467e891e3f226fcf65bc schema:name pubmed_id
58 schema:value 6158685
59 rdf:type schema:PropertyValue
60 N261460a60e30426587d17e9a5bc1c589 schema:volumeNumber 287
61 rdf:type schema:PublicationVolume
62 N28ad8887698f4278bc8f805004a1a1e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Lymphocyte Cooperation
64 rdf:type schema:DefinedTerm
65 N31ef3e795f6d45fe9b08c287fb8c6b96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Female
67 rdf:type schema:DefinedTerm
68 N3e900c463a04437f9f299eae97e0023a rdf:first sg:person.0616307541.57
69 rdf:rest N413b167f28f44285a486b524da7abdff
70 N413b167f28f44285a486b524da7abdff rdf:first sg:person.01065517405.85
71 rdf:rest N080da0e7b36a4e228b7323e65459a0ca
72 N464809203e834335b4af993c30790525 schema:name dimensions_id
73 schema:value pub.1022071545
74 rdf:type schema:PropertyValue
75 N4905b9e9cf274044b74f0533bf055cca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Immunologic Memory
77 rdf:type schema:DefinedTerm
78 N522d521727fe4497bd3f924ae57b5e51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Epitopes
80 rdf:type schema:DefinedTerm
81 N666e83ceff244319905516f960a3c39f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Chickens
83 rdf:type schema:DefinedTerm
84 N786af2b3b8e1466397753a5d73e44bbf schema:name readcube_id
85 schema:value 6927838e8be7e71b80455685da4856b6c6e8fb39774c6471057a40ec98de4e82
86 rdf:type schema:PropertyValue
87 N7d1e6b4fa1444e7d88f0cd6bfad2a2ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Animals
89 rdf:type schema:DefinedTerm
90 N7e050cd32f0a4128a199b7783b7338f6 schema:name nlm_unique_id
91 schema:value 0410462
92 rdf:type schema:PropertyValue
93 N8d687eb44b2f4206a9f24dcc5e21d317 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Antibody Specificity
95 rdf:type schema:DefinedTerm
96 N9932d93a87fe4be9bd71f60a60f69aea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Immunoglobulin Idiotypes
98 rdf:type schema:DefinedTerm
99 Nb772b58fdbdb4242a70b805ef5c70822 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Clone Cells
101 rdf:type schema:DefinedTerm
102 Nbe4720784c1d4780aa383bdde550543c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Antibodies
104 rdf:type schema:DefinedTerm
105 Ndca1e3ae6d2c47b1ac6f8c5d56fb106e schema:issueNumber 5782
106 rdf:type schema:PublicationIssue
107 Ne1d3909fca7c4856876889dce3f04d96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Time Factors
109 rdf:type schema:DefinedTerm
110 Ne4c34cb0ba6b46b7b1cfd4d3e9459483 schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 Ne791a12e098e4da48e9d70294e57b3a9 schema:name doi
113 schema:value 10.1038/287540a0
114 rdf:type schema:PropertyValue
115 Nf6997efa49cb44559e4f4343deef9326 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Muramidase
117 rdf:type schema:DefinedTerm
118 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
119 schema:name Medical and Health Sciences
120 rdf:type schema:DefinedTerm
121 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
122 schema:name Immunology
123 rdf:type schema:DefinedTerm
124 sg:grant.2449296 http://pending.schema.org/fundedItem sg:pub.10.1038/287540a0
125 rdf:type schema:MonetaryGrant
126 sg:grant.2466371 http://pending.schema.org/fundedItem sg:pub.10.1038/287540a0
127 rdf:type schema:MonetaryGrant
128 sg:grant.2634192 http://pending.schema.org/fundedItem sg:pub.10.1038/287540a0
129 rdf:type schema:MonetaryGrant
130 sg:grant.2682469 http://pending.schema.org/fundedItem sg:pub.10.1038/287540a0
131 rdf:type schema:MonetaryGrant
132 sg:journal.1018957 schema:issn 0090-0028
133 1476-4687
134 schema:name Nature
135 rdf:type schema:Periodical
136 sg:person.01065517405.85 schema:familyName Miller
137 schema:givenName Alexander
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065517405.85
139 rdf:type schema:Person
140 sg:person.01141524574.77 schema:familyName Sercarz
141 schema:givenName Eli E.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141524574.77
143 rdf:type schema:Person
144 sg:person.0616307541.57 schema:familyName Metzger
145 schema:givenName Dennis W.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616307541.57
147 rdf:type schema:Person
148 sg:pub.10.1038/281594a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009169346
149 https://doi.org/10.1038/281594a0
150 rdf:type schema:CreativeWork
151 https://app.dimensions.ai/details/publication/pub.1082338542 schema:CreativeWork
152 https://doi.org/10.1002/eji.1830091113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019758731
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/0014-5793(73)80139-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031360817
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/0161-5890(79)90044-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018037696
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1073/pnas.68.10.2616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040269847
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1084/jem.130.3.619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048041155
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1084/jem.144.5.1254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024011231
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1084/jem.146.5.1436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046229624
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1084/jem.148.6.1488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013338384
167 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...