Ontology type: schema:ScholarlyArticle
1980-09
AUTHORSRik Derynck, Erik Remaut, Erik Saman, Patrick Stanssens, Erik De Clercq, Jean Content, Walter Fiers
ABSTRACTThe human fibroblast Interferon gene was inserted in a thermoinducible expression plasmid under control of the phage lambda PL promotor. The primary translation products predicted on the basis of the plasmid constructions were hybrid proteins starting with β-lactamase or phage MS2 polymerase information followed by the total preinterferon. On induction, antiviral activity, whose physico-chemical, immunological and biological characteristics closely corresponded to those of authentic human fibroblast Interferon, was synthesized. Processing to a size compatible with mature but unglycosylated authentic product was observed. More... »
PAGES193-197
http://scigraph.springernature.com/pub.10.1038/287193a0
DOIhttp://dx.doi.org/10.1038/287193a0
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/6159534
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