A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-08

AUTHORS

J. G. Seidman, Philip Leder

ABSTRACT

A mutant immunoglobulin gene has been formed by an abnormal (non V/J) recombination event such that abnormal RNA splicing is required to form a mutant light chain. The structure of the gene suggests that the small palindrome thought to be involved in V/J joining also provides the basis for this abnormal DNA recombination and that the absence of a J segment and RNA splice signal allows an abnormal RNA splicing reaction to occur. More... »

PAGES

779-783

Journal

TITLE

Nature

ISSUE

5775

VOLUME

286

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/286779a0

DOI

http://dx.doi.org/10.1038/286779a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039035652

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6772973


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