Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-08

AUTHORS

Hitoshi Sakano, Richard Maki, Yoshikazu Kurosawa, William Roeder, Susumu Tonegawa

ABSTRACT

At least two types of somatic recombination are necessary for the generation of a complete immunoglobulin gamma 2b gene from germ-line DNA sequences. The first type of recombination consists of the assembly of three separate DNA segments, each encoding a different part of the variable region. The second type of recombination replaces the exons coding for the constant region of the mu chain with those coding for the same region of the gamma 2b chain. The DNA sequencing studies suggest that the two types of recombination operate by different mechanisms. More... »

PAGES

676-683

Journal

TITLE

Nature

ISSUE

5774

VOLUME

286

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/286676a0

    DOI

    http://dx.doi.org/10.1038/286676a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020638070

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6774258


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