Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-06

AUTHORS

Suzanne Cory, Jillian Jackson, Jerry M. Adams

ABSTRACT

Deletions spanning portions of the heavy chain constant region (CH) locus in murine plasmacytomas are revealed by hybridization with cloned immunoglobulin DNA molecules. The pattern of deletions suggests that a lymphocyte clone switches expression of CH genes by successive deletions and that the probable CH gene order is 5′ µ-γ3-γ1-γ2b-γ2a-α3′.

PAGES

450-456

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/285450a0

DOI

http://dx.doi.org/10.1038/285450a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050398699

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6772957


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