Migration of capillary endothelial cells is stimulated by tumour-derived factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-05

AUTHORS

Bruce R. Zetter

ABSTRACT

Angiogenesis, the growth of new blood vessels, occurs normally during osteogenesis, luteinisation and the development of the embryo, and in pathological states such as chronic inflammation, certain immune reactions and neoplasia1. Furthermore, solid tumours have been reported to secrete a diffusible factor which promotes the directional growth of new capillaries towards a growing tumour2. Two events required for the formation of a new capillary in response to an angiogenesis factor in vivo are the migration and subsequent proliferation of capillary endothelial cells3. Progress in purifying angiogenesis factors and studying their action has been hindered, however, by the lack of quantitative in vitro assays for capillary cell migration and proliferation. Recently, we have been able to isolate clonal cell lines of bovine capillary endothelial cells that can be maintained in long-term culture using tumour-conditioned growth medium4. I now report a quantitative in vitro assay for endothelial cell migration based on the phagokinetic track assay of Albrecht-Buehler5. The evidence presented here demonstrates that tumour-derived factors stimulate the migration of capillary endothelial cells whereas the same factors have no effect on the migration of aortic endothelial cells. More... »

PAGES

41-43

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/285041a0

DOI

http://dx.doi.org/10.1038/285041a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014817950

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6990271


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiogenesis Inducing Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aorta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Capillaries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Culture Media", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Growth Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histological Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phagocytosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoma, Experimental", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Children's Hospital Medical Center and the Department of Microbiology and Molecular Genetics, Harvard Medical School, 02115, Boston, Massachusetts", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Surgery, Children's Hospital Medical Center and the Department of Microbiology and Molecular Genetics, Harvard Medical School, 02115, Boston, Massachusetts"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zetter", 
        "givenName": "Bruce R.", 
        "id": "sg:person.01122612403.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122612403.37"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1980-05", 
    "datePublishedReg": "1980-05-01", 
    "description": "Angiogenesis, the growth of new blood vessels, occurs normally during osteogenesis, luteinisation and the development of the embryo, and in pathological states such as chronic inflammation, certain immune reactions and neoplasia1. Furthermore, solid tumours have been reported to secrete a diffusible factor which promotes the directional growth of new capillaries towards a growing tumour2. Two events required for the formation of a new capillary in response to an angiogenesis factor in vivo are the migration and subsequent proliferation of capillary endothelial cells3. Progress in purifying angiogenesis factors and studying their action has been hindered, however, by the lack of quantitative in vitro assays for capillary cell migration and proliferation. Recently, we have been able to isolate clonal cell lines of bovine capillary endothelial cells that can be maintained in long-term culture using tumour-conditioned growth medium4. I now report a quantitative in vitro assay for endothelial cell migration based on the phagokinetic track assay of Albrecht-Buehler5. The evidence presented here demonstrates that tumour-derived factors stimulate the migration of capillary endothelial cells whereas the same factors have no effect on the migration of aortic endothelial cells.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/285041a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5759", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "285"
      }
    ], 
    "keywords": [
      "tumor-derived factors", 
      "capillary endothelial cells", 
      "endothelial cells", 
      "angiogenesis factors", 
      "new capillaries", 
      "certain immune reactions", 
      "aortic endothelial cells", 
      "cell migration", 
      "new blood vessels", 
      "chronic inflammation", 
      "bovine capillary endothelial cells", 
      "immune reactions", 
      "long-term culture", 
      "phagokinetic track assay", 
      "solid tumors", 
      "blood vessels", 
      "clonal cell lines", 
      "lack of quantitative", 
      "endothelial cell migration", 
      "pathological states", 
      "cell lines", 
      "diffusible factors", 
      "subsequent proliferation", 
      "cells", 
      "proliferation", 
      "assays", 
      "factors", 
      "inflammation", 
      "luteinisation", 
      "tumors", 
      "capillaries", 
      "angiogenesis", 
      "same factors", 
      "vivo", 
      "migration", 
      "osteogenesis", 
      "vessels", 
      "quantitative", 
      "response", 
      "evidence", 
      "action", 
      "cells3", 
      "lack", 
      "events", 
      "effect", 
      "embryos", 
      "culture", 
      "growth", 
      "development", 
      "lines", 
      "progress", 
      "reaction", 
      "formation", 
      "state", 
      "directional growth", 
      "neoplasia1", 
      "tumour2", 
      "capillary endothelial cells3", 
      "endothelial cells3", 
      "capillary cell migration", 
      "tumour-conditioned growth medium4", 
      "growth medium4", 
      "medium4", 
      "track assay", 
      "Albrecht-Buehler5"
    ], 
    "name": "Migration of capillary endothelial cells is stimulated by tumour-derived factors", 
    "pagination": "41-43", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014817950"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/285041a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6990271"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/285041a0", 
      "https://app.dimensions.ai/details/publication/pub.1014817950"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T17:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_157.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/285041a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/285041a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/285041a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/285041a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/285041a0'


 

This table displays all metadata directly associated to this object as RDF triples.

195 TRIPLES      21 PREDICATES      109 URIs      101 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/285041a0 schema:about N05f74aa79e344b66bbe7bc67c961cb26
2 N10d8654ec52e4fa687fc5e5f3543aece
3 N138ae41afc7b4488992f8e534288cd15
4 N155e9ce7fb7f4a4d9ffbb4d753eea09c
5 N3247d7d43a34405fb63075a7987de43a
6 N34697b41538e47ceb1fddfa46caa869e
7 N3be8d3acdca9461e82b3e27139983eec
8 N48199a22670440e2afa4659dfdbd616e
9 N6ebbdfe7358943a492b2a6a813a7c57e
10 N72009f93bbd74b21b9304cdb34a3f5b2
11 N87a8c1299d894e779dbe290d7fc7d379
12 Nab74635138274f9baf858b05994e7781
13 Nb3140ca529994826ad1e7178ba7bced6
14 Nbad769db74894f7db8f00287d5545456
15 Nc04e2ba5f8694a00accc89ca26a4b8ef
16 Nf2ed56246e9b4df5a2a152a26b6548db
17 Nfab2430c9f0c4f15988b788eff87557a
18 anzsrc-for:11
19 anzsrc-for:1107
20 schema:author N29efab4f3b5249c996dd9f58520fb651
21 schema:datePublished 1980-05
22 schema:datePublishedReg 1980-05-01
23 schema:description Angiogenesis, the growth of new blood vessels, occurs normally during osteogenesis, luteinisation and the development of the embryo, and in pathological states such as chronic inflammation, certain immune reactions and neoplasia1. Furthermore, solid tumours have been reported to secrete a diffusible factor which promotes the directional growth of new capillaries towards a growing tumour2. Two events required for the formation of a new capillary in response to an angiogenesis factor in vivo are the migration and subsequent proliferation of capillary endothelial cells3. Progress in purifying angiogenesis factors and studying their action has been hindered, however, by the lack of quantitative in vitro assays for capillary cell migration and proliferation. Recently, we have been able to isolate clonal cell lines of bovine capillary endothelial cells that can be maintained in long-term culture using tumour-conditioned growth medium4. I now report a quantitative in vitro assay for endothelial cell migration based on the phagokinetic track assay of Albrecht-Buehler5. The evidence presented here demonstrates that tumour-derived factors stimulate the migration of capillary endothelial cells whereas the same factors have no effect on the migration of aortic endothelial cells.
24 schema:genre article
25 schema:inLanguage en
26 schema:isAccessibleForFree false
27 schema:isPartOf N303e299d980d40f58fed463ccaee2e97
28 Nc956fe0dfe63424aabef544254baea5c
29 sg:journal.1018957
30 schema:keywords Albrecht-Buehler5
31 action
32 angiogenesis
33 angiogenesis factors
34 aortic endothelial cells
35 assays
36 blood vessels
37 bovine capillary endothelial cells
38 capillaries
39 capillary cell migration
40 capillary endothelial cells
41 capillary endothelial cells3
42 cell lines
43 cell migration
44 cells
45 cells3
46 certain immune reactions
47 chronic inflammation
48 clonal cell lines
49 culture
50 development
51 diffusible factors
52 directional growth
53 effect
54 embryos
55 endothelial cell migration
56 endothelial cells
57 endothelial cells3
58 events
59 evidence
60 factors
61 formation
62 growth
63 growth medium4
64 immune reactions
65 inflammation
66 lack
67 lack of quantitative
68 lines
69 long-term culture
70 luteinisation
71 medium4
72 migration
73 neoplasia1
74 new blood vessels
75 new capillaries
76 osteogenesis
77 pathological states
78 phagokinetic track assay
79 progress
80 proliferation
81 quantitative
82 reaction
83 response
84 same factors
85 solid tumors
86 state
87 subsequent proliferation
88 track assay
89 tumor-derived factors
90 tumors
91 tumour-conditioned growth medium4
92 tumour2
93 vessels
94 vivo
95 schema:name Migration of capillary endothelial cells is stimulated by tumour-derived factors
96 schema:pagination 41-43
97 schema:productId N2b2777f31e3c454f8e3bfe11e2cf2583
98 N416c0db2971d46f2a7c3d5d5512e5812
99 Ncffb86d0cabf41ff92103f621c905652
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014817950
101 https://doi.org/10.1038/285041a0
102 schema:sdDatePublished 2021-11-01T17:55
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N1c9260a83f934c0798ac2862cd4abb0f
105 schema:url https://doi.org/10.1038/285041a0
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N05f74aa79e344b66bbe7bc67c961cb26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Capillaries
111 rdf:type schema:DefinedTerm
112 N10d8654ec52e4fa687fc5e5f3543aece schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Animals
114 rdf:type schema:DefinedTerm
115 N138ae41afc7b4488992f8e534288cd15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Growth Substances
117 rdf:type schema:DefinedTerm
118 N155e9ce7fb7f4a4d9ffbb4d753eea09c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Neoplasms, Experimental
120 rdf:type schema:DefinedTerm
121 N1c9260a83f934c0798ac2862cd4abb0f schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 N29efab4f3b5249c996dd9f58520fb651 rdf:first sg:person.01122612403.37
124 rdf:rest rdf:nil
125 N2b2777f31e3c454f8e3bfe11e2cf2583 schema:name pubmed_id
126 schema:value 6990271
127 rdf:type schema:PropertyValue
128 N303e299d980d40f58fed463ccaee2e97 schema:issueNumber 5759
129 rdf:type schema:PublicationIssue
130 N3247d7d43a34405fb63075a7987de43a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Cell Movement
132 rdf:type schema:DefinedTerm
133 N34697b41538e47ceb1fddfa46caa869e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 N3be8d3acdca9461e82b3e27139983eec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Culture Media
138 rdf:type schema:DefinedTerm
139 N416c0db2971d46f2a7c3d5d5512e5812 schema:name dimensions_id
140 schema:value pub.1014817950
141 rdf:type schema:PropertyValue
142 N48199a22670440e2afa4659dfdbd616e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Rats
144 rdf:type schema:DefinedTerm
145 N6ebbdfe7358943a492b2a6a813a7c57e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Sarcoma, Experimental
147 rdf:type schema:DefinedTerm
148 N72009f93bbd74b21b9304cdb34a3f5b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Histological Techniques
150 rdf:type schema:DefinedTerm
151 N87a8c1299d894e779dbe290d7fc7d379 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Angiogenesis Inducing Agents
153 rdf:type schema:DefinedTerm
154 Nab74635138274f9baf858b05994e7781 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Liver Neoplasms, Experimental
156 rdf:type schema:DefinedTerm
157 Nb3140ca529994826ad1e7178ba7bced6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Cells, Cultured
159 rdf:type schema:DefinedTerm
160 Nbad769db74894f7db8f00287d5545456 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Endothelium
162 rdf:type schema:DefinedTerm
163 Nc04e2ba5f8694a00accc89ca26a4b8ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Mice
165 rdf:type schema:DefinedTerm
166 Nc956fe0dfe63424aabef544254baea5c schema:volumeNumber 285
167 rdf:type schema:PublicationVolume
168 Ncffb86d0cabf41ff92103f621c905652 schema:name doi
169 schema:value 10.1038/285041a0
170 rdf:type schema:PropertyValue
171 Nf2ed56246e9b4df5a2a152a26b6548db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Phagocytosis
173 rdf:type schema:DefinedTerm
174 Nfab2430c9f0c4f15988b788eff87557a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Aorta
176 rdf:type schema:DefinedTerm
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
181 schema:name Immunology
182 rdf:type schema:DefinedTerm
183 sg:journal.1018957 schema:issn 0028-0836
184 1476-4687
185 schema:name Nature
186 schema:publisher Springer Nature
187 rdf:type schema:Periodical
188 sg:person.01122612403.37 schema:affiliation grid-institutes:grid.38142.3c
189 schema:familyName Zetter
190 schema:givenName Bruce R.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122612403.37
192 rdf:type schema:Person
193 grid-institutes:grid.38142.3c schema:alternateName Department of Surgery, Children's Hospital Medical Center and the Department of Microbiology and Molecular Genetics, Harvard Medical School, 02115, Boston, Massachusetts
194 schema:name Department of Surgery, Children's Hospital Medical Center and the Department of Microbiology and Molecular Genetics, Harvard Medical School, 02115, Boston, Massachusetts
195 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...