Transforming activity of DNA of chemically transformed and normal cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-04

AUTHORS

Geoffrey M. Cooper, Sharon Okenquist, Lauren Silverman

ABSTRACT

DNA fragments of chemically transformed and normal avian and murine cells induce transformation of NIH 3T3 mouse cells with low efficiencies. High molecular weight DNAs of cells transformed by DNA fragments induce transformation with high efficiencies in secondary transfection assays. It thus seems that endogenous transforming genes of uninfected cells can be activated and efficiently transmitted by transfection. These results are consistent with the hypothesis that normal cells contain genes that are capable of inducing transformation if expressed at abnormal levels. More... »

PAGES

418-421

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/284418a0

DOI

http://dx.doi.org/10.1038/284418a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032667119

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7360280


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinogens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methylcholanthrene", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transformation, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sidney Farber Cancer Institute and Department of Pathology, Harvard Medical School, 02115, Boston, Massachusetts", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Sidney Farber Cancer Institute and Department of Pathology, Harvard Medical School, 02115, Boston, Massachusetts"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cooper", 
        "givenName": "Geoffrey M.", 
        "id": "sg:person.014640065462.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014640065462.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sidney Farber Cancer Institute and Department of Pathology, Harvard Medical School, 02115, Boston, Massachusetts", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Sidney Farber Cancer Institute and Department of Pathology, Harvard Medical School, 02115, Boston, Massachusetts"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okenquist", 
        "givenName": "Sharon", 
        "id": "sg:person.01311713026.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311713026.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sidney Farber Cancer Institute and Department of Pathology, Harvard Medical School, 02115, Boston, Massachusetts", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Sidney Farber Cancer Institute and Department of Pathology, Harvard Medical School, 02115, Boston, Massachusetts"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silverman", 
        "givenName": "Lauren", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/260170a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019128532", 
          "https://doi.org/10.1038/260170a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1980-04", 
    "datePublishedReg": "1980-04-01", 
    "description": "DNA fragments of chemically transformed and normal avian and murine cells induce transformation of NIH 3T3 mouse cells with low efficiencies. High molecular weight DNAs of cells transformed by DNA fragments induce transformation with high efficiencies in secondary transfection assays. It thus seems that endogenous transforming genes of uninfected cells can be activated and efficiently transmitted by transfection. These results are consistent with the hypothesis that normal cells contain genes that are capable of inducing transformation if expressed at abnormal levels.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/284418a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5755", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "284"
      }
    ], 
    "keywords": [
      "DNA fragments", 
      "NIH 3T3 mouse cells", 
      "high molecular weight DNA", 
      "normal cells", 
      "activity of DNA", 
      "molecular weight DNA", 
      "transfection assays", 
      "mouse cells", 
      "transforming genes", 
      "murine cells", 
      "weight DNA", 
      "uninfected cells", 
      "genes", 
      "DNA", 
      "cells", 
      "fragments", 
      "transfection", 
      "assays", 
      "low efficiency", 
      "abnormal levels", 
      "activity", 
      "hypothesis", 
      "transformation", 
      "levels", 
      "efficiency", 
      "results", 
      "high efficiency"
    ], 
    "name": "Transforming activity of DNA of chemically transformed and normal cells", 
    "pagination": "418-421", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032667119"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/284418a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7360280"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/284418a0", 
      "https://app.dimensions.ai/details/publication/pub.1032667119"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_173.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/284418a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/284418a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/284418a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/284418a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/284418a0'


 

This table displays all metadata directly associated to this object as RDF triples.

157 TRIPLES      21 PREDICATES      67 URIs      58 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/284418a0 schema:about N026e25fe82244e629fbd77f3f4240912
2 N1d5221e42fed4bcc98374a959471e34b
3 N279fa511371f45029240f360c1332d7a
4 N388230dd63db496fa17062ab1578e4cb
5 N413224a2d223415dadf418a3080b5a86
6 N4c03002f28574e9fb8058346a8085b04
7 N505c3897576a4fe1b14a2b913ce6fa07
8 N576db715ef834d499eb6a8337bf2367c
9 N71fa8e88f56e4b3f962b824628352a0a
10 N7b0dd81ff8fb42bda1fb0995b1f5e7f7
11 Na45d666b99a149538855b8c6f4637cd6
12 Nce952f3b4a474add822608593c00307d
13 Nf81b2bd035674ec9a4fb72e878935daf
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author N2c48c71ba2224035a825cd86821caa85
17 schema:citation sg:pub.10.1038/260170a0
18 schema:datePublished 1980-04
19 schema:datePublishedReg 1980-04-01
20 schema:description DNA fragments of chemically transformed and normal avian and murine cells induce transformation of NIH 3T3 mouse cells with low efficiencies. High molecular weight DNAs of cells transformed by DNA fragments induce transformation with high efficiencies in secondary transfection assays. It thus seems that endogenous transforming genes of uninfected cells can be activated and efficiently transmitted by transfection. These results are consistent with the hypothesis that normal cells contain genes that are capable of inducing transformation if expressed at abnormal levels.
21 schema:genre article
22 schema:isAccessibleForFree false
23 schema:isPartOf N0cb5308495f743feae5dc4e59c444f99
24 N4ec9c24b39c94611a3da3b2125625994
25 sg:journal.1018957
26 schema:keywords DNA
27 DNA fragments
28 NIH 3T3 mouse cells
29 abnormal levels
30 activity
31 activity of DNA
32 assays
33 cells
34 efficiency
35 fragments
36 genes
37 high efficiency
38 high molecular weight DNA
39 hypothesis
40 levels
41 low efficiency
42 molecular weight DNA
43 mouse cells
44 murine cells
45 normal cells
46 results
47 transfection
48 transfection assays
49 transformation
50 transforming genes
51 uninfected cells
52 weight DNA
53 schema:name Transforming activity of DNA of chemically transformed and normal cells
54 schema:pagination 418-421
55 schema:productId N6287c68e2dfe45099278365ae1ef8fee
56 N9a1faeb629f54860b5599340942f0318
57 Ne4d383b50b1c43b29971c1bc01a35c64
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032667119
59 https://doi.org/10.1038/284418a0
60 schema:sdDatePublished 2022-08-04T16:50
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher Nc9ce8cc69130473f88248bb67ba79603
63 schema:url https://doi.org/10.1038/284418a0
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N026e25fe82244e629fbd77f3f4240912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Cells, Cultured
69 rdf:type schema:DefinedTerm
70 N0cb5308495f743feae5dc4e59c444f99 schema:volumeNumber 284
71 rdf:type schema:PublicationVolume
72 N1d5221e42fed4bcc98374a959471e34b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name DNA, Neoplasm
74 rdf:type schema:DefinedTerm
75 N279fa511371f45029240f360c1332d7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Methylcholanthrene
77 rdf:type schema:DefinedTerm
78 N27e7ad33bcb54417b80ae405b8ce6d26 schema:affiliation grid-institutes:grid.38142.3c
79 schema:familyName Silverman
80 schema:givenName Lauren
81 rdf:type schema:Person
82 N2c48c71ba2224035a825cd86821caa85 rdf:first sg:person.014640065462.81
83 rdf:rest Nc0e0a1c96b7a4dbd9b85e53a82a1eafa
84 N388230dd63db496fa17062ab1578e4cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Genes
86 rdf:type schema:DefinedTerm
87 N413224a2d223415dadf418a3080b5a86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Transfection
89 rdf:type schema:DefinedTerm
90 N4c03002f28574e9fb8058346a8085b04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Carcinogens
92 rdf:type schema:DefinedTerm
93 N4ec9c24b39c94611a3da3b2125625994 schema:issueNumber 5755
94 rdf:type schema:PublicationIssue
95 N505c3897576a4fe1b14a2b913ce6fa07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Transformation, Genetic
97 rdf:type schema:DefinedTerm
98 N576db715ef834d499eb6a8337bf2367c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Molecular Weight
100 rdf:type schema:DefinedTerm
101 N6287c68e2dfe45099278365ae1ef8fee schema:name doi
102 schema:value 10.1038/284418a0
103 rdf:type schema:PropertyValue
104 N71fa8e88f56e4b3f962b824628352a0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name DNA
106 rdf:type schema:DefinedTerm
107 N7ab379417db746c0808793615dcf7394 rdf:first N27e7ad33bcb54417b80ae405b8ce6d26
108 rdf:rest rdf:nil
109 N7b0dd81ff8fb42bda1fb0995b1f5e7f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Animals
111 rdf:type schema:DefinedTerm
112 N9a1faeb629f54860b5599340942f0318 schema:name pubmed_id
113 schema:value 7360280
114 rdf:type schema:PropertyValue
115 Na45d666b99a149538855b8c6f4637cd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cell Transformation, Neoplastic
117 rdf:type schema:DefinedTerm
118 Nc0e0a1c96b7a4dbd9b85e53a82a1eafa rdf:first sg:person.01311713026.71
119 rdf:rest N7ab379417db746c0808793615dcf7394
120 Nc9ce8cc69130473f88248bb67ba79603 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 Nce952f3b4a474add822608593c00307d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Mutation
124 rdf:type schema:DefinedTerm
125 Ne4d383b50b1c43b29971c1bc01a35c64 schema:name dimensions_id
126 schema:value pub.1032667119
127 rdf:type schema:PropertyValue
128 Nf81b2bd035674ec9a4fb72e878935daf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Mice
130 rdf:type schema:DefinedTerm
131 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
132 schema:name Biological Sciences
133 rdf:type schema:DefinedTerm
134 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
135 schema:name Genetics
136 rdf:type schema:DefinedTerm
137 sg:journal.1018957 schema:issn 0028-0836
138 1476-4687
139 schema:name Nature
140 schema:publisher Springer Nature
141 rdf:type schema:Periodical
142 sg:person.01311713026.71 schema:affiliation grid-institutes:grid.38142.3c
143 schema:familyName Okenquist
144 schema:givenName Sharon
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311713026.71
146 rdf:type schema:Person
147 sg:person.014640065462.81 schema:affiliation grid-institutes:grid.38142.3c
148 schema:familyName Cooper
149 schema:givenName Geoffrey M.
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014640065462.81
151 rdf:type schema:Person
152 sg:pub.10.1038/260170a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019128532
153 https://doi.org/10.1038/260170a0
154 rdf:type schema:CreativeWork
155 grid-institutes:grid.38142.3c schema:alternateName Sidney Farber Cancer Institute and Department of Pathology, Harvard Medical School, 02115, Boston, Massachusetts
156 schema:name Sidney Farber Cancer Institute and Department of Pathology, Harvard Medical School, 02115, Boston, Massachusetts
157 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...